PMID: 4903972Jan 10, 1970Paper

Experimental and clinical studies on rifampicin in treatment of leprosy

British Medical Journal
R J ReesM F Waters

Abstract

Rifampicin showed high activity against experimental leprosy, inhibiting the multiplication of dapsone-sensitive and dapsone-resistant strains of Mycobacterium leprae in mice fed 5 mg./kg. body weight. In a formal pilot-type trial on six previously untreated patients with active lepromatous leprosy, rifampicin (600 mg. daily by mouth) was as effective as standard treatment with dapsone. Myco. leprae, however, appeared to be killed more rapidly by rifampicin than by dapsone or other antileprosy drugs so far studied. This was confirmed on a further 10 patients, including two with dapsone resistance, and from the infectivity in mice of bacilli recovered from patients during treatment with rifampicin or dapsone. These results are consistent with the bactericidal activity of rifampicin against other micro-organisms, which could be important to the chemotherapy of leprosy, since all antileprosy drugs in current use are bacteriostatic.

References

Jan 1, 1967·Biochimica Et Biophysica Acta·G HartmannJ Nüesch
Dec 1, 1968·Tubercle·G CanettiF Grumbach
Jan 1, 1966·Chemotherapy·N MaggiP Sensi

❮ Previous
Next ❯

Citations

Nov 1, 1994·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·R H Gelber
Oct 1, 1995·European Journal of Drug Metabolism and Pharmacokinetics·N ChouchaneA Benakis
Apr 5, 2002·Current Treatment Options in Neurology·Sharon P. Nations, Richard J. Barohn
Dec 1, 1984·Vaccine·D E Stewart-Tull
May 1, 1995·Clinics in Dermatology·Y Sugita
Jul 1, 1971·The Journal of Laryngology and Otology·I Friedmann
Jan 1, 1974·Japanese Journal of Microbiology·Y Matsuo
Sep 1, 1975·British Journal of Pharmacology·B W AllenA G Weddell
Jun 25, 2008·Antimicrobial Agents and Chemotherapy·Fe Eleanor F PardilloRobert H Gelber
Jan 21, 1978·British Medical Journal·M F WatersR H Gelber
Nov 14, 1981·British Medical Journal·M F Waters
Jan 11, 1992·BMJ : British Medical Journal·R H GelberT H Rea
Jun 1, 1971·Postgraduate Medical Journal·H A Reimann
Nov 2, 2013·PLoS Neglected Tropical Diseases·Grace L DavisLinda B Adams
Oct 20, 2001·Indian Journal of Medical Sciences
Apr 4, 2003·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Arvind M Dhople, Kenji Namba
Sep 15, 1975·Experientia·A C McDougallD G Grahame-Smith
Jan 1, 1967·Transactions of the Royal Society of Tropical Medicine and Hygiene·R J Rees
Aug 26, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Angélique LewiesDu Plessis Lissinda Hester
Sep 15, 2011·Tropical Medicine & International Health : TM & IH·Maninder S SetiaJean-François Boivin
Oct 3, 2015·Médecine et maladies infectieuses·F ReibelA Aubry
Jan 1, 1970·Transactions of the Royal Society of Tropical Medicine and Hygiene·R J Rees, A G Weddell
Dec 7, 2007·Journal of Pharmaceutical and Biomedical Analysis·Jianfang LiuZhonggui He
Jan 1, 1990·International Journal of Dermatology·V N Sehgal, Joginder
May 1, 1975·International Journal of Dermatology·D L Leiker
Feb 23, 2010·Nihon Hansenbyō Gakkai zasshi = Japanese journal of leprosy : official organ of the Japanese Leprosy Association·Masanao Makino
Jul 1, 1976·Repura. Leprosy·Y Matsuo, S Utsunomiya
Apr 1, 1973·Tropical Doctor·R J Rees
Nov 14, 2001·American Journal of Clinical Dermatology·M Ramos-e-Silva, P F Rebello
Jun 1, 1987·The Medical Journal of Australia·C R Boughton, A R Lloyd
Oct 7, 1972·The Medical Journal of Australia·C R Boughton
Nov 1, 1971·Journal of Bacteriology·R J WhiteL G Silvestri
Jul 1, 1988·Clinical Microbiology Reviews·R C HastingsS G Franzblau
Jul 1, 1997·Antimicrobial Agents and Chemotherapy·R H Gelber

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy & Infectious Diseases

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Allergy & Infectious Diseases (ASM)

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Related Papers

British Medical Journal
M F Waters
Nihon Hansenbyō Gakkai zasshi = Japanese journal of leprosy : official organ of the Japanese Leprosy Association
R P Singh
© 2021 Meta ULC. All rights reserved