PMID: 3768644Oct 1, 1986Paper

Experimental and clinical study of lactulose in obstructive jaundice

The British Journal of Surgery
J A Pain, M E Bailey

Abstract

The role of lactulose in preventing endotoxaemia in obstructive jaundice has been investigated. A prospective study was performed on 24 consecutive patients with obstructive jaundice undergoing surgery. Twelve patients were given oral lactulose before operation and were compared with twelve controls. Endotoxaemia was reduced in peroperative portal (P less than 0.05) and postoperative systemic (P less than 0.05) blood samples in the lactulose treated group, and a significant fall (P less than 0.05) occurred in the postoperative 24 h creatinine clearances in controls compared with the lactulose treated group. Results from animal experiments in which oral lactulose reduced endotoxin related mortality in obstructive jaundice (P less than 0.05), and the in vitro demonstration of a direct anti-endotoxic action of lactulose suggest that its beneficial action is due in part to an inactivation of endotoxin.

References

Jan 1, 1978·American Journal of Surgery·L H Blumgart
Jan 1, 1979·Infection·E MagliuloO Armignacco
Oct 1, 1976·The British Journal of Surgery·M E Bailey
Dec 1, 1985·The British Journal of Surgery·J A PainM E Bailey
Feb 1, 1966·Journal of Bacteriology·H SelyeL Bertók
Mar 1, 1983·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H van VugtL L Thomas
Oct 1, 1980·The Australian and New Zealand Journal of Surgery·D R Hunt

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Citations

Aug 1, 1997·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·J PozsárA Pap
Dec 1, 1989·American Journal of Surgery·C P Page
Jan 1, 1992·Nutrition Research Reviews·K LundholmR Sandström
Jan 1, 1996·Journal of Gastroenterology and Hepatology·M C Puntis, W G Jiang
Jan 1, 1994·Gut·P A Van LeeuwenR I Wesdorp
Apr 16, 1998·Gut·W D ClementsB J Rowlands
Sep 6, 2011·The Veterinary Clinics of North America. Small Animal Practice·Stephen J Mehler
Mar 12, 2008·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·R AnderssonB Tingstedt
May 16, 2009·Clinics in Liver Disease·Jacqueline G O'LearyLawrence S Friedman
Jul 1, 1989·American Journal of Surgery·A B LumsdenJ Alspaugh
Feb 9, 2006·The Journal of Surgical Research·Diamantis PlachourasMichalis Safioleas
Nov 1, 1990·Journal of the American Geriatrics Society·J D Fulton, D J Mack
Jan 1, 1992·Scandinavian Journal of Gastroenterology. Supplement·J W GreveW A Buurman
Dec 1, 1988·The British Journal of Surgery·C J Cahill, J A Pain
Mar 1, 1988·The British Journal of Surgery·J D GreigN A Matheson
May 1, 1990·The British Journal of Surgery·J D Fulton, D J Mack
May 1, 1989·The British Journal of Surgery·F Martínez-RódenasA Sitges-Serra
Jul 1, 1993·The British Journal of Surgery·W D ClementsB J Rowlands
Jun 1, 1992·The British Journal of Surgery·A Sitges-SerraJ M Gubern
Apr 1, 1995·The British Journal of Surgery·K R GardinerB J Rowlands
Jul 1, 1995·The British Journal of Surgery·B J FogartyT Diamond
Dec 1, 1989·The Journal of Pathology·Y Shibayama
Oct 1, 2010·European Journal of Gastroenterology & Hepatology·Adam UsluYavuz Coşkun
Jan 1, 1997·Scandinavian Journal of Gastroenterology. Supplement·H O Conn
Jul 29, 2016·World Journal of Gastroenterology : WJG·Jaymon PatelSonu Dhillon
Jan 1, 1997·Scandinavian Journal of Gastroenterology. Supplement·B Vogt, F J Frey
Jan 1, 1997·Scandinavian Journal of Gastroenterology. Supplement·A P HoudijkP A Van Leeuwen

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