Experimental and Numerical Modeling of Aerosol Delivery for Preterm Infants

International Journal of Environmental Research and Public Health
Iñigo AramendiaMiguel Angel Gomez-Solaetxe

Abstract

Respiratory distress syndrome (RDS) represents one of the major causes of mortality among preterm infants, and the best approach to treat it is an open research issue. The use of perfluorocarbons (PFC) along with non-invasive respiratory support techniques has proven the usefulness of PFC as a complementary substance to achieve a more homogeneous surfactant distribution. The aim of this work was to study the inhaled particles generated by means of an intracorporeal inhalation catheter, evaluating the size and mass distribution of different PFC aerosols. In this article, we discuss different experiments with the PFC perfluorodecalin (PFD) and FC75 with a driving pressure of 4-5 bar, evaluating properties such as the aerodynamic diameter (Da), since its value is directly linked to particle deposition in the lung. Furthermore, we develop a numerical model with computational fluid dynamics (CFD) techniques. The computational results showed an accurate prediction of the airflow axial velocity at different downstream positions when compared with the data gathered from the real experiments. The numerical validation of the cumulative mass distribution for PFD particles also confirmed a closer match with the experimental data measured a...Continue Reading

References

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Mar 18, 2011·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Xabier MurgiaCarmen Rey-Santano
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Feb 18, 2016·Aerosol Science and Technology : the Journal of the American Association for Aerosol Research·Zeeshan H SyedainArif Somani

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Citations

Jan 10, 2019·Pharmaceutics·Iñigo AramendiaMiguel Angel Gomez-Solaetxe
Jun 3, 2021·International Journal of Environmental Research and Public Health·Sergio A ChillonXabier Mendaza-Sagastizabal
Jul 3, 2021·Children·Mandy BrasherElie G Abu Jawdeh

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