Experimental angioplasty: lessons from the laboratory

AJR. American Journal of Roentgenology
P C BlockD Elmer

Abstract

To elucidate the pathophysiologic mechanisms of transluminal angioplasty, normal coronary arteries in dogs, atherosclerotic human coronary arteries, and atherosclerotic vessels in rabbits were studied after angioplasty. Normal canine coronary arteries showed desquamation of endothelium, exposure of subendothelial connective tissue elements, and deposition of a carpet of platelets, fibrin, and occasional red blood cells. Administration of low molecular weight dextran before angioplasty decreased platelet deposition. Atherosclerotic human coronary arteries studied postmortem showed enlargement of lumen size after angioplasty due to splitting and disruption of the plaque and the underlying media. Endothelial desquamation and splitting of the plaque were also seen in atherosclerotic vessels in rabbits after angioplasty. The amount of splitting seems to depend on the relative size of the stenotic vessel and the inflated angioplasty balloon. Animals studied sequentially showed retraction of the separated intimal plaque elements and further lumen enlargement after 1-2 weeks. Two mechanisms of successful angioplasty are suggested by these studies: (1) desquamation of superficial plaque elements and (2) splitting of the plaque with retr...Continue Reading

Citations

Jan 1, 1984·Cardiovascular and Interventional Radiology·G L WolfE J Ring
Jan 1, 1981·Urologic Radiology·T A SosJ H Laragh
Nov 1, 1990·Journal of the American College of Cardiology·A FarbF D Kolodgie
Oct 1, 1992·Journal of the American College of Cardiology·B N PotkinM B Leon
Mar 1, 1989·Clinical Radiology·A M Belli, D C Cumberland
Apr 1, 1987·Journal of the American College of Cardiology·J L BlackshearR M Califf
Mar 30, 1985·British Medical Journal·N P Silverton
Mar 1, 1990·Journal of Neurology, Neurosurgery, and Psychiatry·M M BrownJ Waterston
Sep 1, 1990·Catheterization and Cardiovascular Diagnosis·K P NguyenS H Stertzer
Nov 1, 1981·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A C Novick, R A Straffon
Aug 1, 1991·AORN Journal·K G DoughertyM J Nangle
Dec 14, 2001·Journal of Vascular and Interventional Radiology : JVIR·G A GardinerK L Sullivan
Jan 1, 1986·The American Journal of Cardiology·A JainR Roberts
Dec 1, 1986·Current Problems in Cardiology·B F Waller
Sep 1, 1987·American Heart Journal·R I HambyR Ricciardi
Mar 1, 1983·The American Journal of Cardiology·D R HolmesT A Orszulak
Feb 1, 1990·European Journal of Vascular Surgery·E MattssonD Bergqvist
Jan 1, 1983·Clinical Radiology·D C Cumberland
Jul 1, 1983·Seminars in Nuclear Medicine·C D TeatesC R Ayers
Jun 15, 1984·The American Journal of Cardiology·D P FaxonT J Ryan
Dec 1, 1983·The British Journal of Surgery·W B CampbellR N Baird
Mar 1, 1997·Stroke; a Journal of Cerebral Circulation·F CrawleyM M Brown
May 1, 1987·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·R T LyonS Glagov
May 1, 1982·Circulation·P C BlockJ T Fallon
Mar 6, 2019·Toxicologic Pathology·Taylor A Spangler, Scott A Katzman
Jul 24, 2015·Biomedical Optics Express·Thomas LanvinDemetri Psaltis
Aug 1, 1990·The Journal of Urology·S A SlavisT Maatman
Feb 1, 1986·Current Problems in Cardiology·W H Frishman, K P Miller

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.