PMID: 6357789Oct 1, 1983

Experimental animal model of surgical wound infection applicable to antibiotic prophylaxis

European Journal of Clinical Microbiology
F MoesgaardT Justesen

Abstract

Wound infection, defined as accumulation of pus draining spontaneously or after opening of the wound, developed in 19 out of 22 guinea pigs (86%) after intraincisional contamination with 10(7) Escherichia coli plus 10(8) Bacteroides fragilis before wound closure. Antibiotic prophylaxis with gentamicin plus clindamycin significantly reduced the wound sepsis rate from 86% to 29% (p less than 0,001). Pus for bacteriological studies was available in all cases of wound infection but one, and culture always revealed both Escherichia coli and Bacteroides fragilis. The animal model presented employs widely accepted criteria for wound infection, and avoids culture of tissue homogenates.

References

Feb 24, 1979·The Medical Journal of Australia·P S HuntA Sali
Aug 1, 1979·The Australian and New Zealand Journal of Surgery·E S HughesJ P Masterton
Mar 8, 1973·Medical Microbiology and Immunology·T JustesenT Hattel
Feb 1, 1967·Annals of Surgery·J W AlexanderW A Altemeier
May 16, 1964·Lancet·U LJUNGQVIST

Citations

Dec 1, 1984·European Journal of Clinical Microbiology·F MoesgaardT Justesen
Jun 1, 1984·European Journal of Clinical Microbiology·F MoesgaardJ H Scheibel
Aug 1, 1986·European Journal of Clinical Microbiology·F MoesgaardM Tvede
Jan 1, 1984·Scandinavian Journal of Infectious Diseases. Supplementum
Jun 28, 2011·Virulence·Tianhong DaiMichael R Hamblin

Related Concepts

Antibiotics
Bacteroides fragilis
Bacteroides Infections
Dalacin C
Escherichia Coli Infections
Gentacycol
Cavia porcellus
Premedication
Surgical Wound Infection

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