Experimental anxiety induced by histaminergics in mast cell-deficient and congenitally normal mice

Pharmacology, Biochemistry, and Behavior
Y Ikarashi, M Yuzurihara

Abstract

To clarify the effect of mast cell-derived histamine release in the brain on anxiety, histaminergics-induced anxiety-like behaviors were examined by a light/dark test in mast cell-deficient (W/Wv) and congenitally normal (+/+) mice. In +/+ mice, when cimetidine (an H2 receptor antagonist) was coadministered with thioperamide (a neuronal histamine releaser acting via inhibition of H3 autoreceptors) or Compound 48/80 (C48/80, a selective histamine releaser from mast cells), the time spent in the light zone and the number of crossings between light and dark zones in a light/dark test decreased significantly, suggesting induction of anxiety. In W/Wv mice, however, experimental anxiety was induced by coadministration of thioperamide-cimetidine, but not C48/80-cimetidine. These results suggest that both nonneuronal mast cell-derived histamine and neuronal histamine play an important role in inducing experimental anxiety.

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Citations

May 9, 2012·Naunyn-Schmiedeberg's Archives of Pharmacology·Preet AnandNirmal Singh
Jul 13, 2013·Trends in Neurosciences·Rae Silver, James P Curley
Nov 14, 2008·Proceedings of the National Academy of Sciences of the United States of America·Katherine M NautiyalRae Silver
Nov 16, 2005·Behavioural Pharmacology·Mohammad-Reza ZarrindastAli Roohbakhsh
Oct 21, 2005·Basic & Clinical Pharmacology & Toxicology·Mohammad-Reza ZarrindastAli Roohbakhsh
May 19, 2006·Journal of Biochemical and Biophysical Methods·Zsombor KoszegiIstván Hernádi
Nov 23, 2005·Journal of Neuroimmunology·Péter KovácsMárta Wilhelm
May 20, 2016·Journal of Immunology Research·Ruoyu WangDongmei Li
May 19, 2010·Journal of Pediatric Gastroenterology and Nutrition·Jennifer V SchurmanCraig A Friesen

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