Experimental arterial allografting under low and therapeutic dosages of cyclosporine for immunosuppression

Transplantation
M VischjagerM J Jacobs

Abstract

The aim of this study was to investigate performance of preserved arterial allografts under the protection of a high-dose and a low-dose immunosuppressive regimen, with cyclosporine (CsA). Dog carotid arteries were harvested and stored for 14 days at 4 degrees C in University of Wisconsin organ preservation solution. Segments (6 cm) of carotid artery were orthotopically and bilaterally implanted in mongrel dogs (n = 18). CsA was given in two dosage regimens: 25 mg/kg/day (group I, n = 7) and 10 mg/kg/day (group II, n = 7). The control group received no CsA (group III, n=4). After 3 months of implantation, patency was assessed by angiography. The grafts were excised for investigation of vessel wall and endothelial function and morphology. For assessment of function in vitro, slices of arterial segments were connected as ring preparations to an isometric force transducer and immersed in a 5 ml organ bath (37 degrees C) containing Tyrode's solution. The contractile response was examined by adding 40 mM KCl and phenylephrine (100 microM) to the organ bath; endothelium-dependent relaxation was examined by adding methacholine (100 microM). Morphology was assessed semiquantitatively. The functional responses to KCl, phenylephrine (Phe...Continue Reading

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Citations

Feb 24, 2001·The Annals of Thoracic Surgery·R E ShaddyJ A Hawkins
Feb 6, 2004·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Farzad Moien-AfshariIsmail Laher
Nov 4, 2006·Expert Review of Cardiovascular Therapy·Cammon B Arrington, Robert E Shaddy
Mar 25, 2005·Pediatric Transplantation·Robert E Shaddy, Thomas C Fuller
Mar 1, 2007·Transplant International : Official Journal of the European Society for Organ Transplantation·Ivan MatiaMilos Adamec
Oct 29, 2002·The Annals of Thoracic Surgery·Robert E Shaddy, John A Hawkins
Sep 27, 2002·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·M PragerG Kretschmer
Jun 7, 2006·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·I MatiaO Viklicky
Sep 10, 2002·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Flemming ForsbergBarry B Goldberg

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