Experimental arthritis exacerbates Aggregatibacter actinomycetemcomitans-induced periodontitis in mice

Journal of Clinical Periodontology
Celso Martins Queiroz-JuniorTarcília Aparecida da Silva

Abstract

This study aimed to investigate whether chronic antigen-induced arthritis (AIA) influences infection-induced periodontitis (PD) in mice and whether PD modifies the clinical course of AIA. The contribution of anti-TNF-α therapy was also evaluated. The PD was induced in C57BL/6 mice by oral infection with Aggregatibacter actinomycetemcomitans. AIA was induced after infection. Anti-TNF-α and chlorhexidine therapies were used to investigate the role of TNF-α and oral infection on PD and AIA interaction. Maxillae, knee joints, lymph nodes and serum samples were used for histomorphometric, immunoenzymatic and/or real time-PCR analyses. Antigen-induced arthritis exacerbated alveolar bone loss triggered by PD infection. In contrast, PD did not influence AIA in the evaluated time-points. PD exacerbation was associated with enhanced production of IFN-γ in maxillae and expression of the Th1 transcription factor tBET in submandibular lymph nodes. Increased serum levels of IL-6 and C-reactive protein were also detected. Anti-TNF-α and antiseptic therapies prevented the development and exacerbation of infectious-PD. Anti-TNF-α therapy also resulted in reduced expression of IFN-γ, TNF-α and IL-17 in maxillae. Altogether, the current results i...Continue Reading

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Sep 6, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Celso Martins Queiroz-JuniorTarcília Aparecida da Silva

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Citations

Mar 5, 2013·Current Opinion in Rheumatology·Clifton O Bingham, Malini Moni
Jul 1, 2014·The American Journal of Pathology·Trinidad Montero-MelendezMauro Perretti
Mar 22, 2016·Anaerobe·Jôice Dias CorrêaTarcília Aparecida da Silva
Jul 15, 2015·European Journal of Pharmacology·Patricia R Souza, Lucy V Norling
May 1, 2017·Molecular Aspects of Medicine·Mauro Perretti, Lucy V Norling
Dec 2, 2017·Periodontology 2000·Philip M Preshaw
Feb 1, 2019·Annals of the Rheumatic Diseases·Guillaume CourbonHubert Marotte
May 13, 2017·Journal of Clinical Periodontology·Sabrina G de AquinoJoni A Cirelli
Jul 14, 2018·Nature Reviews. Rheumatology·Christopher D Buckley, Helen M McGettrick
Aug 29, 2019·Journal of Clinical Medicine·Eduardo Gómez-BañuelosFelipe Andrade
Sep 22, 2019·International Journal of Molecular Sciences·Rafael Scaf de MolonMarije I Koenders
Jun 12, 2019·Scientific Reports·Jôice Dias CorrêaDana T Graves
May 10, 2020·Periodontology 2000·Peter Mark Bartold, Isabel Lopez-Oliva
Sep 1, 2021·Periodontology 2000·Jerián González-Febles, Mariano Sanz

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