Experimental asexual blood stage malaria immunity

Current Protocols in Immunology
F H Amante, M F Good

Abstract

This unit describes three methods for investigating the immune response to murine malaria parasites. Immunization protocols using recombinant fragments of the merozoite surface protein-1 of Plasmodium yoelii, whole blood stage malaria parasites, and live infection with parasitized red blood cells from a Plasmodium-infected donor are provided. Methods for chemotherapeutic drug care of Plasmodium-infected mice and for inducing malaria by adoptive transfer of antigen-specific T cells are included. Finally, support protocols describe methods for growing, maintaining, and cryopreserving murine asexual blood stage malaria parasites and for preparing blood stage antigen for use in ELISAs.

References

Jan 1, 1979·The American Journal of Tropical Medicine and Hygiene·D W Roberts, W P Weidanz
Sep 1, 1983·Infection and Immunity·J L Grun, W P Weidanz
Jun 25, 1993·Science·A W Taylor-RobinsonF Y Liew

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Citations

Jan 1, 2014·Infection and Immunity·Sarah R AuclairChris S Lantz

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