Aug 1, 1977

Experimental autoimmune encephalomyelitis in mice: antigen binding lymphocytes to basic protein of myelin in susceptible and resistant strains

Journal of Immunogenetics
C C BernardI R Mackay

Abstract

Antigen-binding lymphocytes (ABL) to basic protein of myelin (BPM) were demonstrable in the thymus and spleen of various strains of mice. Counts of ABL did not differ in strains resistant and susceptible to EAE, and did not differ when human or murine 125I-labelled BPM was used as a labelled antigen to detect ABL. After injection with mouse spinal cord and adjuvants, under conditions known to be immunogenic and encephalitogenic for susceptible strains of mice, counts of ABL increased two- to four-fold in suceptible strains but did not icnrease in resistant strains. Antigen binding could not be accounted for by the attachment to cells of cytophilic antibody with specificity for BPM, because such antibody was seldom demonstrable even after immunization. Inferences from the study were: (i) that tolerate (non-responsiveness) to certain autoantigens at least must depend on control over continually present antigen-reactive lymphocytes rather than on any lack of capacity to recognize antigen; (ii) differences in susceptible and resistant strains are evident after, rather than before, immunization.

  • References12
  • Citations8

References

Mentioned in this Paper

T-Lymphocyte
Mice, Inbred BALB C
Antigen Binding
Spleen
Lymphocytes as Percentage of Blood Leukocytes (Lab Test)
Myelin Sheath
Neoplasm of Uncertain or Unknown Behavior of Thymus
Murine
Antigenic Specificity
Lymphoid Cells

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