PMID: 7520474Sep 1, 1994Paper

Experimental autoimmune panencephalitis and uveoretinitis transferred to the Lewis rat by T lymphocytes specific for the S100 beta molecule, a calcium binding protein of astroglia

The Journal of Experimental Medicine
K KojimaC Linington

Abstract

The pathogenic potential of autoimmune T cell responses to nonmyelin autoantigens was investigated in the Lewis rat using the astrocyte-derived calcium binding protein S100 beta, as a model nonmyelin autoantigen. The Lewis rat mounts a vigorous RT1B1 (major histocompatibility complex class II) restricted autoimmune response to an immunodominant S100 beta epitope (amino acid residues 76-91). The adoptive transfer of S100 beta-specific T cell lines induced a severe inflammatory response in the nervous system, but only minimal neurological dysfunction in naive syngeneic recipients. The inability of S100 beta-specific T cell transfer to induce severe disease was associated with a decreased recruitment of ED1+ macrophages into the central nervous system (CNS) in comparison with that seen in severe experimental autoimmune encephalomyelitis (EAE) induced by the adoptive transfer of myelin basic protein (MBP)-specific T line cells. Moreover, unlike encephalitogenic MBP-specific T cell lines, S100 beta-specific T cell lines exhibited no cytotoxic activity in vitro. Histopathological analysis also revealed striking differences in the distribution of inflammatory lesions in MBP- and S100 beta-specific T cell-mediated disease. In contrast ...Continue Reading

References

Dec 1, 1992·Immunology Today·I R Cohen
Nov 15, 1991·The Journal of Comparative Neurology·J Gehrmann, G W Kreutzberg
Nov 1, 1991·Ophthalmology·M J LucarelliR Y Foos
Jul 23, 1991·Biochimica Et Biophysica Acta·J Syha-JedelhauserK Reske
Feb 1, 1991·Journal of Neuroscience Research·W F HickeyH Kimura
Jun 1, 1991·Brain : a Journal of Neurology·D BarnesW I McDonald
Oct 1, 1990·The Journal of Experimental Medicine·I HuitingaC D Dijkstra
Feb 1, 1989·European Journal of Immunology·J ChlubaJ T Epplen
Oct 1, 1989·Trends in Neurosciences·W I McDonald, D Barnes
Feb 1, 1987·Journal of the Neurological Sciences·P J ShawD Bates
Sep 1, 1985·Journal of Neurochemistry·R JensenD M Watterson
Jun 9, 1965·Biochemical and Biophysical Research Communications·B W Moore
Sep 1, 1984·Journal of Neuroimmunology·C LinningtonP L Woodhams
Jun 1, 1984·Journal of Neurochemistry·V E ShashouaB W Moore
Jan 1, 1993·Immunology Today·B ArnoldG J Hämmerling

❮ Previous
Next ❯

Citations

Jan 1, 1996·Springer Seminars in Immunopathology·R Martin, H McFarland
Jan 1, 1996·Springer Seminars in Immunopathology·M Bradl
Apr 7, 2011·Acta Neuropathologica·Maria PohlMonika Bradl
Jan 16, 2007·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Farzin ForooghianPaul O'Connor
Sep 15, 2006·Documenta Ophthalmologica. Advances in Ophthalmology·Farzin ForooghianPaul O'Connor
Apr 17, 2007·Journal of Clinical Immunology·Farzin ForooghianHans-Michael Dosch
Jun 1, 1995·Immunology Today·R HohlfeldM Salvetti
Jul 30, 1999·Journal of Neuroimmunology·R M Ransohoff
Aug 3, 1999·Journal of Neuroimmunology·K Kohyama, Y Matsumoto
Dec 2, 1999·Journal of Neuroimmunology·B GloddekW Arnold
Nov 16, 2002·Progress in Retinal and Eye Research·Stephan R Thurau, Gerhild Wildner
Feb 1, 2000·Molecular Medicine Today·R GoldK V Toyka
Oct 6, 2007·Nature Reviews. Immunology·Alan G Baxter
Jul 7, 1998·The Journal of Experimental Medicine·T LitzenburgerA Iglesias
Jul 2, 1999·Brain : a Journal of Neurology·K W WestlandJ G McLeod
Dec 22, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·R Hohlfeld
Dec 1, 1995·Neuropathology and Applied Neurobiology·C Linington
Apr 1, 1995·Immunological Reviews·D A Hafler, H L Weiner
Feb 1, 1996·Immunological Reviews·H WekerleK Kojima
Oct 23, 2003·Journal of Neurology, Neurosurgery, and Psychiatry·M Bradl, R Hohlfeld
Mar 18, 2005·Annual Review of Immunology·Mireia Sospedra, Roland Martin
Dec 1, 1995·The Journal of Clinical Investigation·C P GenainS L Hauser
Sep 17, 1998·The Journal of Clinical Investigation·R WeissertT Olsson
Dec 14, 1999·Journal of the Neurological Sciences·E Silber, M K Sharief
Nov 1, 2001·Proceedings of the National Academy of Sciences of the United States of America·A CornetR S Liblau
Sep 25, 1999·Journal of Neuroimmunology·P Diaz-VillosladaS L Hauser
Jul 1, 1996·Journal of Neuroimmunology·T M PribylA T Campagnoni

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.