PMID: 7543143Aug 1, 1995Paper

Experimental autoimmune peripheral neuritis induced in BALB/c mice by myelin basic protein-specific T cell clones

The Journal of Experimental Medicine
S Abromson-LeemanM E Dorf

Abstract

In vivo adoptive transfer of CD4+ T helper cell type 1 clones reactive with autologous myelin basic protein (MBP) may initiate an inflammatory demyelinating disease of the central nervous system called experimental autoimmune encephalomyelitis. Although MBP is also a component of peripheral nervous system (PNS) myelin, previous studies have failed to demonstrate inflammation in the PNS induced by MBP-reactive T cells. Here, we report on two MBP-specific T cell clones that preferentially initiate inflammatory and demyelinating peripheral neuritis when adoptively transferred to syngeneic recipients. The MBP epitope recognized by these clones spans the junction of exons 6 and 7 and, therefore, is present in the 21- and 18.5-kD but not the 14- and 17-kD MBP isoforms, in which exon 5 is spliced to exon 7. The data suggest that MBP may be processed and presented differently in the central nervous system and PNS, and they provide evidence for MBP as a potential target for autoimmune reactions in the PNS.

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Citations

Jan 1, 1996·Springer Seminars in Immunopathology·H P HartungG Giegerich
Jun 14, 2002·Neuromuscular Disorders : NMD·Mathias MäurerRalf Gold
Apr 6, 2007·Nature Clinical Practice. Neurology·Gerd Meyer zu HörsteBernd C Kieseier
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Emanual MaverakisEli E Sercarz
Jan 10, 2008·Neuro-degenerative Diseases·B FrickerF René
Oct 15, 1998·Proceedings of the National Academy of Sciences of the United States of America·L Z ChenG J Thorbecke
Jun 22, 1999·Journal of Neuroimmunology·J ZhuH G Ljunggren
Feb 6, 2002·Springer Seminars in Immunopathology·A Iglesias
Nov 3, 2007·Journal of Neuroimmunology·Sara Abromson-LeemanMartin E Dorf
Sep 8, 2007·Muscle & Nerve·Gerd Meyer zu HörsteBernd C Kieseier
May 11, 2012·Journal of the Peripheral Nervous System : JPNS·Betty Soliven
Nov 29, 2017·Journal of Neuroinflammation·David SchafflickGerd Meyer Zu Horste
Oct 26, 2005·Journal of Leukocyte Biology·Mitsuyuki MuranoVincent K Tsiagbe
Sep 28, 2002·Current Opinion in Neurology·Mathias Mäurer, Ralf Gold
Apr 29, 1999·Brain Pathology·R GoldH P Hartung
Feb 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stephan EllmerichDaniel M Altmann

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