PMID: 9553646Apr 29, 1998Paper

Experimental autoimmune prostatitis: in vivo induction of the autoimmune response to lymphocytic soluble factors. Alterations at the endocrine metabolism level

American Journal of Reproductive Immunology : AJRI
G P Diserio, E Nowotny

Abstract

In rats, immunization with male accessory gland (MAG) extract promotes experimental autoimmune vesicle prostatitis. A specific mononuclear cell-mediated immune response and prostate androgen metabolism impairment in MAG-immunized rats were observed. The possibility that lymphocytic soluble factors (SoFs) can regulate the local steroid metabolism in these rats directly was studied. We investigated whether the SoFs released by MAG-sensitized lymphocytes are capable of modifying the prostatic androgen metabolism and whether they induce histologic lesions "in vivo" when they are inoculated, carried by liposomes, into untreated rats. "In vitro" enzymatic [3H]-5 alpha-dihydrotestosterone bioconversion and histologic studies were performed with prostates from SoF-treated rats (LK rats). The obtained 3 alpha/beta-hydroxysteroid-oxidoreductase activities showed that LK rat values were significantly lower than in controls: 79.0 +/- 2.5 vs 158.7 +/- 10.2 pmol/min/mg protein, respectively (P < 0.01). In the histologic studies, LK rat prostates showed focalized mononuclear infiltrates of various degrees, whereas control rats showed non-atypic modification of the gland. These results indicate that SoFs (probably total lymphokines) contribute...Continue Reading

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Citations

Apr 25, 2008·The Journal of Urology·Michel A Pontari, Michael R Ruggieri
Nov 25, 2003·The Journal of Urology·Gustavo P Diserio, Edgar Nowotny
Aug 18, 2004·The Journal of Urology·Michel A Pontari, Michael R Ruggieri
Apr 25, 2007·Archives of Andrology·Xiao-hui ZhouZhi-heng Zhou
Nov 18, 2020·International Urology and Nephrology·Yuqian LiuXiaohui Zhou

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