Experimental axonopathy induced by immunization with Campylobacter jejuni lipopolysaccharide from a patient with Guillain-Barré syndrome

Journal of Neuroimmunology
Christina M CaporaleAntonino Uncini

Abstract

New Zealand white rabbits were immunized with a lipopolysaccharide (LPS) extracted from a Campylobacter jejuni HS:19 strain isolated from a GBS patient expressing GM1 and GD1a-like epitopes, Freund's adjuvant (group I) and Freund's adjuvant plus keyhole lympet hemocyanin (KLH) (group II). Both groups showed high titers of anti-LPS and anti-GM1 and lower titers of anti-GD1b and anti-GD1a antibodies. Weakness and axonal degeneration in sciatic nerves was detected in 1/11 of group I and 6/7 of group II. This model replicates, at least in part, the pathogenetic process hypothesized in the human axonal GBS with antiganglioside antibodies post C. jejuni infection and indicates that KLH plays an additional role in neuropathy induction.

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Citations

Nov 16, 2013·Lancet Neurology·Satoshi Kuwabara, Nobuhiro Yuki
Apr 7, 2012·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Antonino Uncini, Satoshi Kuwabara
Jan 10, 2016·Journal of Molecular Neuroscience : MN·Rozina NoristaniStephanie C Joachim
Nov 29, 2007·Journal of the Peripheral Nervous System : JPNS·Nobuhiro Yuki, Satoshi Kuwabara
Apr 30, 2013·Muscle & Nerve·Antonino UnciniMargherita Capasso
Jul 6, 2006·Journal of Neuroimmunology·Christina M CaporaleAntonino Uncini
Apr 13, 2010·Journal of the Neurological Sciences·Francesca NotturnoAntonino Uncini
Mar 22, 2007·Muscle & Nerve·Nobuhiro Yuki
Jun 6, 2009·Expert Review of Neurotherapeutics·Antonino Uncini, Nobuhiro Yuki
Jan 4, 2013·Journal of the Peripheral Nervous System : JPNS·Helmar C LehmannHans-Peter Hartung
Apr 16, 2020·Acta Neuropathologica Communications·Irina TsymalaMonika Bradl
Jan 16, 2010·International Journal of Immunopathology and Pharmacology·M T CencioniA Uncini
Jun 4, 2015·Journal of Neuromuscular Diseases·Delmont Emilien, Willison Hugh
Aug 28, 2020·Frontiers in Public Health·Nicola Principi, Susanna Esposito
Jun 10, 2009·International Journal of Immunopathology and Pharmacology·F NotturnoA Uncini
Feb 16, 2021·Frontiers in Aging Neuroscience·Kathleen M Hagen, Shalina S Ousman
Nov 22, 2007·Biochimica Et Biophysica Acta·Gustavo A NoresFernando J Irazoqui
Nov 10, 2021·Expert Review of Clinical Immunology·Norman Latov

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