PMID: 8949723Aug 1, 1996Paper

Experimental Bacillus cereus post-traumatic endophthalmitis and treatment with ciprofloxacin

The British Journal of Ophthalmology
D V AlfaroP Liggett

Abstract

Bacillus species remain an important cause of post-traumatic endophthalmitis, often causing permanent visual loss. Twenty two rabbits were used to evaluate the clinical and histological findings of Bacillus cereus experimental post-traumatic endophthalmitis. Eyes that had received a scleral laceration and surgical repair were inoculated with Bacillus cereus. Thirty four other rabbits were used to evaluate the efficacy of intravitreal ciprofloxacin in treating experimental disease. Animals developed a post-traumatic endophthalmitis that closely mimicked human disease, characterised by a rapidly progressive and destructive endophthalmitis. Histological evaluation revealed retinal detachment, retinal necrosis, and the infiltration of inflammatory cells into the subretinal space. Intravitreal ciprofloxacin (100 micrograms) prevented the development of disease when given 1 hour and 6 hours after trauma and inoculation. Clinical and histological examination of experimental Bacillus cereus post-traumatic endophthalmitis suggests that retinal detachment and retinal necrosis play important roles in visual loss. Ciprofloxacin may be of benefit in the management of certain intraocular infections following penetrating injury.

References

Apr 1, 1992·Ophthalmology·F Z el BabaP E Liggett
Jan 1, 1990·The British Journal of Ophthalmology·R HemadyA S Baker
Dec 15, 1990·American Journal of Ophthalmology·G N KervickD Miller
Mar 1, 1987·Archives of Ophthalmology·G B Schemmer, W T Driebe
Mar 1, 1986·Archives of Ophthalmology·B P Conway, P A Campochiaro
Apr 1, 1987·Ophthalmology·J C AffeldtG D Jarus
Aug 15, 1985·American Journal of Ophthalmology·D J D'AmicoK R Kenyon
Apr 1, 1984·Archives of Ophthalmology·G S BrintonG W Abrams
Aug 1, 1982·Ophthalmology·C A PuliafitoC S Foster
Jul 1, 1994·The British Journal of Ophthalmology·D B DavidB A Noble

❮ Previous
Next ❯

Citations

Oct 3, 2001·Ophthalmology·T DasUNKNOWN Endophthalmitis Research Group
Apr 1, 2000·Microbes and Infection·A KotirantaM Haapasalo
Jul 29, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Wai-Man ChanDennis S C Lam
Sep 30, 1999·The British Journal of Ophthalmology·O CekiçS O Kayaalp
Sep 1, 2000·The British Journal of Ophthalmology·O CekiçA Bozkurt
Apr 4, 2008·Investigative Ophthalmology & Visual Science·Brandt J WiskurMichelle C Callegan
Mar 15, 2011·Survey of Ophthalmology·Neelakshi BhagatMarco Zarbin
May 8, 2016·Progress in Retinal and Eye Research·Roger A AstleyMichelle C Callegan
Jul 30, 2004·Clinical & Experimental Ophthalmology·Rohan W EssexPenelope J Allen
Apr 24, 2007·International Ophthalmology Clinics·Nadia K Waheed, Lucy H Young
Nov 3, 2009·European Journal of Ophthalmology·Hani S Al-MezaineAhmed M Abu El-Asrar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.