PMID: 11901930Mar 21, 2002Paper

Experimental Barrett's esophagus and the origin of intestinal metaplasia

Chest Surgery Clinics of North America
Manuel Pera, Miguel Pera

Abstract

Many questions remain unanswered regarding the pathogenesis and the cell origin of Barrett's esophagus. Recent studies suggest that progenitor cell populations, which are presumed to reside at the basal layer in the squamous epithelium and at the esophageal glands duct epithelium, may differentiate into a glandular phenotype leading to the development of columnar epithelium in the distal esophagus. Other studies also support the hypothesis that cardiac epithelium may precede the occurrence of specialized intestinal metaplasia. It remains unclear whether cardiac-type epithelium in Barrett's esophagus arises from squamous epithelium or from migration of native cardiac epithelium at the EGJ into the distal esophagus. Experimental animal models of chronic reflux esophagitis, although with some shortcomings when researchers extrapolate the study data to the human situation, have provided interesting insights into possible mechanisms associated with the occurrence of Barrett's esophagus. A better understanding of the molecular mechanisms regulating the development of Barrett's esophagus is necessary for developing new strategies directed toward prevention and treatment of this metaplastic condition with a potential risk for malignant...Continue Reading

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Citations

Apr 19, 2007·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Manuel PeraRichard Poulsom
Jan 19, 2010·Gastroenterology·Stuart Jon SpechlerKenneth K Wang
May 19, 2011·Journal of Gastroenterology·Yukie KohataTetsuo Arakawa
Feb 5, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Lina ForssellOlof Akre
Sep 1, 2007·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Yan Li, Robert C G Martin
Jan 17, 2008·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·G SarosiStuart Jon Spechler
Apr 12, 2015·Digestive Diseases and Sciences·Yukie KohataTetsuo Arakawa
Mar 16, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Lina ForssellAkre Olof
Jun 16, 2012·Pathology Research International·Atul BhardwajHaresh Mani
Oct 1, 2019·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Vicente Munitiz RuizPascual Parrilla
Jun 17, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Rhonda F SouzaStuart Jon Spechler

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