Experimental benznidazole treatment of Trypanosoma cruzi II strains isolated from children of the Jequitinhonha Valley, Minas Gerais, Brazil, with Chagas disease

Memórias do Instituto Oswaldo Cruz
Jaquelline Carla Valamiel de Oliveira-SilvaM Lana

Abstract

Trypanosoma cruzi strains from distinct geographic areas show differences in drug resistance and association between parasites genetic and treatment response has been observed. Considering that benznidazole (BZ) can reduce the parasite burden and tissues damage, even in not cured animals and individuals, the goal is to assess the drug response to BZ of T. cruzi II strains isolated from children of the Jequitinhonha Valley, state of Minas Gerais, Brazil, before treatment. Mice infected and treated with BZ in both phases of infection were compared with the untreated and evaluated by fresh blood examination, haemoculture, polymerase chain reaction, conventional (ELISA) and non-conventional (FC-ALTA) serologies. In mice treated in the acute phase, a significant decrease in parasitaemia was observed for all strains. Positive parasitological and/or serological tests in animals treated during the acute and chronic (95.1-100%) phases showed that most of the strains were BZ resistant. However, beneficial effect was demonstrated because significant reduction (p < 0.05%) and/or suppression of parasitaemia was observed in mice infected with all strains (acute phase), associated to reduction/elimination of inflammation and fibrosis for two/...Continue Reading

References

Nov 1, 1992·Transactions of the Royal Society of Tropical Medicine and Hygiene·S G AndradeA O Luquetti
Oct 1, 1991·Memórias do Instituto Oswaldo Cruz·M CarneiroE Chiari
Oct 1, 1990·Revista Da Sociedade Brasileira De Medicina Tropical·H de O Ferreira
Jan 1, 1987·Transactions of the Royal Society of Tropical Medicine and Hygiene·L S Filardi, Z Brener
Jan 1, 1996·Revista Da Sociedade Brasileira De Medicina Tropical·S G Andrade, J B Magalhães
Jul 11, 2000·Revista Do Instituto De Medicina Tropical De São Paulo·M S BragaA R Teixeira
Jan 4, 2001·Clinical and Diagnostic Laboratory Immunology·F D CordeiroA J Romanha
Jun 5, 2001·The American Journal of Tropical Medicine and Hygiene·L Lauria-PiresA R Teixeira
May 7, 2002·Memórias do Instituto Oswaldo Cruz·José Rodriques Coura, Solange L de Castro
Aug 14, 2002·Experimental Parasitology·M J de O ToledoW L Tafuri
Oct 22, 2002·Acta Tropica·Paulo Marcos da Matta GuedesMaria Terezinha Bahia
Dec 25, 2002·Antimicrobial Agents and Chemotherapy·Max Jean de Ornelas ToledoMarta de Lana
Jun 14, 2003·Revista Da Sociedade Brasileira De Medicina Tropical·Edson L P CamandarobaSonia G Andrade
Apr 22, 2004·Archives of Oral Biology·Kátia L M MaltosJanetti N Francischi
Mar 29, 2005·Antimicrobial Agents and Chemotherapy·Simone GarciaMilena B P Soares
Apr 12, 2005·Revista Da Sociedade Brasileira De Medicina Tropical·Rozália Figueira CamposSonia G Andrade
Nov 1, 2006·Current Opinion in Infectious Diseases·Sergio Sosa-Estani, Elsa Leonor Segura
Sep 24, 2009·Memórias do Instituto Oswaldo Cruz·J Antonio Marin-NetoUNKNOWN BENEFIT Investigators
Dec 23, 2009·Memórias do Instituto Oswaldo Cruz·B ZingalesUNKNOWN Second Satellite Meeting
Apr 30, 2010·Memórias do Instituto Oswaldo Cruz·Alvaro José RomanhaZilton de Araújo Andrade
Jan 10, 2012·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Bianca ZingalesNancy R Sturm
Nov 8, 2012·Tropical Medicine & International Health : TM & IH·Ana P M TestonMax J O Toledo
Aug 29, 2013·Revista Da Sociedade Brasileira De Medicina Tropical·Jaquelline Carla Valamiel de Oliveira E SilvaMarta de Lana
Nov 20, 2013·Antimicrobial Agents and Chemotherapy·R ViottiUNKNOWN Latin American Network for Chagas Disease, NHEPACHA
Apr 1, 1993·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·M de L HiguchiF Pileggi

❮ Previous
Next ❯

Citations

May 4, 2016·The American Journal of Tropical Medicine and Hygiene·Beatriz Cancino-FaureCristina Riera
Dec 7, 2016·Frontiers in Microbiology·Dexin ZengBaoguang Li
Feb 16, 2018·Experimental Parasitology·Julián Ernesto Nicolás GulinFacundo García-Bournissen

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
ELISA

Software Mentioned

BENEFIT
Leica QWin
Prism

Related Concepts