Experimental Burkholderia pseudomallei infection of pigs

Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health
H NajdenskiA Vesselinova

Abstract

Experimental infection with Burkholderia pseudomallei was successfully produced after a single intravenous challenge of 2-month-old pigs with a dose of 5.0 x 10(9) bacterial cells. Clinical, paraclinical and morphological findings of the infectious process and post-infectious immunity were examined up to day 30 post infection (p.i.). A transient and short hyperthermia accompanied by enhanced and longer demonstrated pulse frequency. An increased erythrocyte sedimentation rate and tachypnea were observed too after clinical examination. The infection starts with significant leucopenia, and a reduced number of alveolar and peritoneal macrophages which have been overcome in the latest intervals of infection. In contrast, the phagocytic activity of leucocytes was statistically increased during the course of infection and up to day 15 p.i. in the case of alveolar macrophages. Burkholderia pseudomallei was able to colonize the lungs during the whole experiment and was only present 3 days in the spleen and mesenterial lymph nodes (MLN). Significant antibody response was developed as early as day 7 p.i. Hyperaemia, haemorrhages and necrotic foci were found in the brain, liver spleen and MLN. Lung tissue was also hyperaemic, with formatio...Continue Reading

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Citations

Nov 5, 2004·Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health·L D Sprague, H Neubauer
Oct 29, 2005·Médecine et maladies infectieuses·V KeluangkhotM Strobel
Jun 28, 2011·The American Journal of Pathology·Laura ConejeroGregory J Bancroft
Nov 5, 2008·Expert Review of Vaccines·Sara K Bondi, Joanna B Goldberg
Jan 18, 2020·Veterinary Sciences·Wiyada KwanhianApichai Tuanyok

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