PMID: 36487Feb 1, 1979

Experimental central hypertension produced by chemical degeneration of the locus coeruleus in the rat

Japanese Circulation Journal
M OgawaM Ozaki


The role of noradrenergic neurons originating from the locus coeruleus (LC) in blood pressure regulation was studied by stereotaxic administration of 6-hydroxydopamine (6-OHDA) into the LC in Wistar-Kyoto rats. The administration of 6-OHDA (12 micrograms/6 microliters) into the bilateral LC resulted in hypertension and tachycardia, which lasted for 12 days and gradually returned to the levels observed before administration. The systolic blood pressure and heart rate were 172 mmHg and 460 beats/min on the mean respectively, one day after administration. The induced hypertension and tachycardia were closely correlated with the depletion of norepinephrine (NE) content in the cortex and the medulla-pons in rats in a hypertensive state. The correlation between the NE content of the cortex and blood pressure was particularly marked (r = -0.793, p less than 0.02). Furthermore, destructive change of the LC was observed histologically in the hypertensive rats. They hypertension was completely prevented by pretreatment with desipramine before 6-OHDA administration. These findings suggest that 6-OHDA induced degeneration, probably mainly in the dorsal bundle originating from the LC and in the LC itself. It is suggested, therefore, that lo...Continue Reading

Related Concepts

Cortex Bone Disorders
Abnormal Degeneration
Adrenal Cortex Diseases
Entire Medulla Oblongata
Systolic Blood Pressure Measurement
Diastolic Blood Pressure
Nerve Degeneration
Norepinephrine, (+, -)-Isomer
Adrenergic alpha-Antagonists

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