PMID: 1202898Dec 18, 1975Paper

Experimental cerebral ischemia in Mongolian gerbils. II. Changes in carbohydrates

Acta Neuropathologica
B B MrsuljaI Klatzo

Abstract

A cerebral ischemia was produced by unilateral ligation of the common carotid artery in the neck of Mongolian gerbils (Meriones unguiculatus), which are frequently characterized by deficiencies in the circulus of Willis. Concentrations of glucose, lactate, pyruvate and glycogen were measured in the hemisphere on the side of occlusion and in the contralateral control hemisphere of animals sacrificed after 5, 15 and 30 min, as well as after 1,3,5 and 9 hrs of carotid clamping. Significant decrease of glucose, and increase in lactate and pyruvate concentration were found in the hemisphere ipsilateral to occlusion; the extent of the changes was proportional to the duration of the ischemia. After an initial fall, an increase in the glycogen content occurred in the later stages of ischemia. Glycogen, glucose, lactate and pyruvate were determined also at 1, 5, 20 hrs and 1 week intervals following release of an occlusion lasting for 1 hr. Return to normal values of glucose and pyruvate was seen at 1 hr after release. The lactate and glycogen levels were significantly raised on the occluded side after 20 hrs release. An increased level of glycogen was observed as long as 1 week after a 1-hr carotid occlusion.

References

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Citations

Jul 1, 1982·Neurochemical Research·M S Abel, D W McCandless
Aug 1, 1977·Journal of the Neurological Sciences·R F DodsonV S Achar
Dec 1, 1992·Journal of the Neurological Sciences·I GustafsonT Wieloch
May 31, 1982·Life Sciences·T Yanagihara, J T McCall
Aug 1, 1992·Pharmacology, Biochemistry, and Behavior·F Colbourne, D Corbett
Jan 14, 1987·Neuroscience Letters·E WesterbergT Wieloch
Jan 1, 1991·Neuroscience·R Schmidt-Kastner, T F Freund
Nov 1, 1992·Brain Research Bulletin·E TabuchiK Kogure
Apr 1, 1993·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·C K Petito, I A Halaby
Sep 1, 1992·Epilepsy Research·D G FujikawaC G Wasterlain
Mar 7, 2002·Clinica Chimica Acta; International Journal of Clinical Chemistry·Ming-Shih LeeFu-Chou Cheng
Mar 14, 2002·European Journal of Pharmacology·Maria A CataniaGioacchino Calapai
Sep 29, 1999·Journal of the Neurological Sciences·M SadowskiM J Mossakowski

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