Experimental cerebral vasospasm: resolution by iloprost

Acta neurochirurgica
N EgemenR K Türker


A new stable analogue of prostacyclin, iloprost, was tested on the basilar artery of anaesthetized rabbits constricted by electrical stimulation and intracisternal injection of autologous blood. The vasospasm induced by these stimuli was effectively relieved (about 100%) by topical application of iloprost, a stable analogue of prostacyclin (PGI2), and no constriction occurred on further stimulation within one hour. The mechanisms of the action of iloprost and its possible therapeutic value in subarachnoid haemorrhage are discussed.


Apr 1, 1979·Prostaglandins·C E Chapleau, R P White
Aug 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·M HambergB Samuelsson
Aug 22, 1986·European Journal of Pharmacology·H E Aksulu, R K Türker
Jan 1, 1988·Prostaglandins, Leukotrienes, and Essential Fatty Acids·R K TürkerZ S Ercan
Mar 1, 1985·European Journal of Cancer & Clinical Oncology·D BronP Stryckmans
Aug 1, 1985·Surgical Neurology·S HaciyakupoğluA Yücesoy
Nov 1, 1983·Journal of Neurosurgery·T FukumoriA Sukenaga
Aug 1, 1980·Journal of Neurosurgery·C E ChapleauJ T Robertson
Apr 1, 1982·Surgical Neurology·O R Blaumanis, P A Grady

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Mar 1, 1993·General Pharmacology·N EgemenA Unlü
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Mar 1, 1990·Prostaglandins, Leukotrienes, and Essential Fatty Acids·S PalaogluR K Turker
Jan 1, 1991·Acta neurochirurgica·K OhnoY Matsushima

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