Experimental cerebral vasospasm: resolution by iloprost

Acta neurochirurgica
N EgemenR K Türker

Abstract

A new stable analogue of prostacyclin, iloprost, was tested on the basilar artery of anaesthetized rabbits constricted by electrical stimulation and intracisternal injection of autologous blood. The vasospasm induced by these stimuli was effectively relieved (about 100%) by topical application of iloprost, a stable analogue of prostacyclin (PGI2), and no constriction occurred on further stimulation within one hour. The mechanisms of the action of iloprost and its possible therapeutic value in subarachnoid haemorrhage are discussed.

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Citations

Mar 1, 1993·General Pharmacology·N EgemenA Unlü
Apr 5, 2000·European Journal of Pharmacology·M BuemiF Tomasello
Apr 6, 2013·Journal of Cardiothoracic Surgery·Gokhan LafciHandan Ankarali
Feb 4, 2010·Acta neurochirurgica·Omür GünaldiCicek Bayindir
Dec 1, 1995·Neurosurgery·R G HempelmannA Ziegler
Mar 1, 1990·Prostaglandins, Leukotrienes, and Essential Fatty Acids·S PalaogluR K Turker
Jan 1, 1991·Acta neurochirurgica·K OhnoY Matsushima

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