Experimental characterization and constitutive modeling of the mechanical behavior of the human trachea

Medical Engineering & Physics
O TrabelsiM Doblaré

Abstract

Cartilage and smooth muscle constitute the main structural components of the human central airways, their mechanical properties affect the flow in the trachea and contribute to the biological function of the respiratory system. The aim of this work is to find out the mechanical passive response of the principal constituents of the human trachea under static tensile conditions and to propose constitutive models to describe their behavior. Histological analyses to characterize the tissues and mechanical tests have been made on three human trachea specimens obtained from autopsies. Uniaxial tensile tests on cartilaginous rings and smooth muscle were performed. Tracheal cartilage was considered an elastic material and its Young's modulus and Poisson's coefficient were determined fitting the experimental curves using a Neo-Hookean model. The smooth muscle was proved to behave as a reinforced hyperelastic material with two families of collagen fibers, and its non-linearity was investigated using the Holzapfel strain-energy density function for two families of fibers to fit the experimental data obtained from longitudinal and transversal cuts. For cartilage, fitting the experimental curves to an elastic model, a Young's modulus of 3.3...Continue Reading

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Citations

May 19, 2010·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·A Pérez del PalomarM Doblaré
Feb 2, 2011·Journal of Biomechanical Engineering·M MalvèM Doblaré
Aug 10, 2011·Journal of Biomechanical Engineering·M MalvèM Doblaré
Apr 17, 2014·Journal of Biomechanics·Ross L WalengaGobalakrishnan Sundaresan
May 2, 2014·The Laryngoscope·Matthew C JonesPaul M Weinberger
Nov 12, 2013·Journal of the Mechanical Behavior of Biomedical Materials·Jinxing HuoE Kristofer Gamstedt
Apr 27, 2012·Journal of Biomechanics·Zhongzhao TengManuel Doblare
Jun 26, 2014·Computer Methods in Biomechanics and Biomedical Engineering·O TrabelsiM Doblaré
Oct 11, 2012·Computer Methods in Biomechanics and Biomedical Engineering·O TrabelsiM Doblaré
Jan 5, 2017·International Journal for Numerical Methods in Biomedical Engineering·Kun Gou, Thomas J Pence
Jan 18, 2018·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Gary LinkovNancy Pleshko
Dec 12, 2017·Artificial Organs·Fabio Gava Aoki, Henrique Takachi Moriya
Sep 13, 2016·Journal of Biomechanical Engineering·Farzaneh SafshekanMohammad B Shadmehr
Jan 13, 2018·Cartilage·Christine M PaukenDavid G Lott
Apr 21, 2017·Respiratory Research·Scott J HollisterSebastian K Hollister
Aug 16, 2016·Tissue Engineering. Part a·Liping ZhaoLaura E Niklason
Nov 28, 2017·Biomechanics and Modeling in Mechanobiology·Donnacha J McGrathPeter E McHugh
Dec 8, 2020·Journal of the Mechanical Behavior of Biomedical Materials·David BerardDavid Restrepo
Jan 23, 2021·Journal of Biomaterials Applications·Jinping WangPengcheng Cui
Mar 26, 2021·Computer Methods in Biomechanics and Biomedical Engineering·Dhananjay Radhakrishnan SubramaniamEphraim J Gutmark
Jul 10, 2019·Journal of the Mechanical Behavior of Biomedical Materials·E GirardB Nottelet
Apr 8, 2021·International Journal for Numerical Methods in Biomedical Engineering·Marta TullioAndrea Aliverti
Jun 28, 2021·Computers in Biology and Medicine·Tareq Zobaer, Alok Sutradhar
Apr 9, 2018·ACS Biomaterials Science & Engineering·Elizabeth M Boazak, Debra T Auguste

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