Experimental Characterization of the Chronic Constriction Injury-Induced Neuropathic Pain Model in Mice

Neurochemical Research
Banulata GopalsamyEnoch Kumar Perimal

Abstract

Number of ligations made in the chronic constriction injury (CCI) neuropathic pain model has raised serious concerns. We compared behavioural responses, nerve morphology and expression of pain marker, c-fos among CCI models developed with one, two, three and four ligations. The numbers of ligation(s) on sciatic nerve shows no significant difference in displaying mechanical and cold allodynia, and mechanical and thermal hyperalgesia throughout 84 days. All groups underwent similar levels of nerve degeneration post-surgery. Similar c-fos level in brain cingulate cortex, parafascicular nuclei and amygdala were observed in all CCI models compared to sham-operated group. Therefore, number of ligations does not impact intensity of pain symptoms, pathogenesis and neuronal activation. A single ligation is sufficient to develop neuropathic pain, in contrast to the established model of four ligations. This study dissects and characterises the CCI model, ascertaining a more uniform animal model to surrogate actual neuropathic pain condition.

References

Jun 1, 1970·Annals of Surgery·R W Postlethwait
Jan 30, 1973·Acta Neuropathologica·Y Olsson, K Kristensson
Apr 1, 1994·Mayo Clinic Proceedings·S A Cross
Nov 8, 2001·European Journal of Pharmacology·M Zimmermann
Sep 19, 2002·Pain·Megumi ShimoyamaNaohito Shimoyama
Oct 31, 2003·Neurochemical Research·Robert M Sapolsky
Nov 20, 2003·Neuroscience Letters·Minoru NaritaTsutomu Suzuki
Nov 9, 2005·The Journal of Pain : Official Journal of the American Pain Society·Kunjumon Ittira VadakkanMin Zhuo
Jan 4, 2006·Brain Research Reviews·Gila Moalem, David J Tracey
Feb 21, 2006·The European Journal of Neuroscience·Xavier NadalRafael Maldonado
Oct 4, 2006·Neuron·James N Campbell, Richard A Meyer
Dec 15, 2006·Pain Practice : the Official Journal of World Institute of Pain·K VissersT Meert
Jan 6, 2007·Brain, Behavior, and Immunity·Nurcan UçeylerClaudia Sommer
Sep 4, 2007·European Journal of Pharmacology·Daisuke KodamaMitsuo Tanabe
Sep 23, 2008·Glia·John W Griffin, Wesley J Thompson
Nov 3, 2009·Biochimica Et Biophysica Acta·Mariapia Colleoni, Paola Sacerdote
Mar 30, 2010·Annual Review of Neuroscience·Michael P Coleman, Marc R Freeman
Jul 12, 2011·European Journal of Pharmacology·Amteshwar Singh Jaggi, Nirmal Singh
Sep 1, 2011·Journal of Neuroinflammation·Andrew D GaudetMatt S Ramer
Jan 17, 2012·Muscle & Nerve·Ranjan GuptaTahseen Mozaffar
Sep 25, 2012·Experimental Physiology·Maria OsikowiczBarbara Przewlocka
Oct 27, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Chuan LiangLin Mei
Oct 31, 2012·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Katarzyna Starowicz, Barbara Przewlocka

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Citations

Aug 30, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Banulata GopalsamyEnoch Kumar Perimal
Oct 21, 2020·Naunyn-Schmiedeberg's Archives of Pharmacology·Muhammad ShahidZia Ud Din
May 5, 2021·The European Journal of Neuroscience·Svenja KankowskiKirsten Haastert-Talini
May 25, 2021·British Journal of Pharmacology·Marta BrykKatarzyna Starowicz
Aug 28, 2021·Biomedicines·Kjeld Morten MohrChristian Bjerggaard Vaegter

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