Experimental Characterization of the Chronic Constriction Injury-Induced Neuropathic Pain Model in Mice

Neurochemical Research
Banulata GopalsamyEnoch Kumar Perimal


Number of ligations made in the chronic constriction injury (CCI) neuropathic pain model has raised serious concerns. We compared behavioural responses, nerve morphology and expression of pain marker, c-fos among CCI models developed with one, two, three and four ligations. The numbers of ligation(s) on sciatic nerve shows no significant difference in displaying mechanical and cold allodynia, and mechanical and thermal hyperalgesia throughout 84 days. All groups underwent similar levels of nerve degeneration post-surgery. Similar c-fos level in brain cingulate cortex, parafascicular nuclei and amygdala were observed in all CCI models compared to sham-operated group. Therefore, number of ligations does not impact intensity of pain symptoms, pathogenesis and neuronal activation. A single ligation is sufficient to develop neuropathic pain, in contrast to the established model of four ligations. This study dissects and characterises the CCI model, ascertaining a more uniform animal model to surrogate actual neuropathic pain condition.


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Aug 30, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Banulata GopalsamyEnoch Kumar Perimal
Oct 21, 2020·Naunyn-Schmiedeberg's Archives of Pharmacology·Muhammad ShahidZia Ud Din
May 5, 2021·The European Journal of Neuroscience·Svenja KankowskiKirsten Haastert-Talini
May 25, 2021·British Journal of Pharmacology·Marta BrykKatarzyna Starowicz
Aug 28, 2021·Biomedicines·Kjeld Morten MohrChristian Bjerggaard Vaegter

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