Experimental cholesterol granuloma. Histopathological and histochemical studies

The Journal of Laryngology and Otology
F HiraideN Miyakogawa

Abstract

The authors have induced experimentally middle-ear effusions and cholesterol granulomas one month and later after tubal obstruction in squirrel monkeys. Cholesterol crystallization has occurred frequently in the middle-ear fluids of three-and six-month-animals, and, typical cholesterol granulomas were noted in four of the eight middle ears of six-month-monkeys. The shape and size of the cholesterol crystals were variable, depending upon the surrounding cells of fluid. In middle-ear effusion, the crystals formed rather large rectangular structures, which tended to become smaller and thinner, as the granulomas developed. The granuloma containing cholesterol crystals was rich in various oxidative and hydrolytic enzymes. The large cells surrounding the crystals show intense-to-strong enzyme activity and probably play a phagocytic role in the developing and healing processes of the granuloma.

References

May 1, 1979·The Journal of Laryngology and Otology·I FRIEDMANN, M D Graham
Mar 1, 1979·Acta Oto-laryngologica·W KuijpersE C Willart
Mar 1, 1976·The Annals of Otology, Rhinology, and Laryngology·G T Nager, T S Vanderveen
Feb 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·T Friedmann
Feb 1, 1974·Physiology & Behavior·J K Friedmann
Jul 1, 1972·Archives of Otolaryngology·F Hiraide, M M Paparella
Apr 1, 1970·Archives of Otolaryngology·T S MainD J Lim
Aug 1, 1970·The Annals of Otology, Rhinology, and Laryngology·M M PaparellaY Kaneko
Feb 1, 1971·The Annals of Otology, Rhinology, and Laryngology·F H Linthicum
Apr 1, 1971·The Annals of Otology, Rhinology, and Laryngology·F H Linthicum
Feb 1, 1968·The Annals of Otology, Rhinology, and Laryngology·G ZechnerE Holopainen
Mar 1, 1967·Archives of Otolaryngology·M M Paparella, D J Lim
Aug 1, 1958·The Journal of Laryngology and Otology·A TUMARKIN
Aug 1, 1958·The Journal of Laryngology and Otology·J F BIRRELL
Mar 1, 1959·The Annals of Otology, Rhinology, and Laryngology·I FRIEDMANN

Citations

Mar 25, 2008·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Michael P CastilloPeter S Roland
Mar 4, 2000·Surgical Neurology·L Cristante, M A Puchner
May 1, 1997·Journal of Neurosurgery·M B EisenbergO Al-Mefty
Mar 28, 2003·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Linghui LuoJibao Wang
Mar 28, 2006·The Annals of Thoracic Surgery·Heyman LuckrazAhmed Azzu
Jan 1, 1985·Auris, Nasus, Larynx·F Hiraide, H Kakoi
Aug 1, 1989·The Journal of Laryngology and Otology·S Bütler, R Grossenbacher
May 16, 2013·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Marcia R S Ilha, Carie Wisell
Mar 5, 2016·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Alex D SweeneyMatthew L Carlson
Jan 25, 2003·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Robert K Jackler, Michael Cho
Oct 7, 2017·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Golda GrinblatMario Sanna
Mar 13, 2014·Allergy & Rhinology·Nicholas L DeepBradford A Woodworth
Oct 27, 2010·The Journal of Laryngology and Otology·G Dhanasekar, N S Jones
May 1, 1986·Acta Oto-laryngologica·T Palva, A Helin
Feb 13, 2003·Clinical & Experimental Ophthalmology·Dinesh SelvaJack Rootman
Nov 6, 2003·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Laurence J DiNardoAristides Sismanis
Jul 1, 1984·The Annals of Otology, Rhinology & Laryngology. Supplement·Y Nomura

Related Concepts

Metazoa
Epicholesterol
Polymorphism, Crystallization
Tympanic Cavity
Granuloma
Genus Saimiri

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