PMID: 9525823Apr 3, 1998Paper

Experimental cisplatin neuronopathy in rats and the effect of retinoic acid administration

Journal of Neuro-oncology
Giovanni TrediciGuido Cavaletti

Abstract

Peripheral nervous system alterations were induced in adult rats by administration of cisplatin (CDDP) 2 mg/kg twice weekly for 4.5 weeks. Dorsal root ganglion neurons showed pathological changes. Morphometric determinations demonstrated a reduction in size of the somatic, nuclear and nucleolar area. The nucleoli were the most involved subcellular structures. Nerve conduction velocity and the tail-flick test for pain were both significantly altered in CDDP treated rats, whereas the rota-rod test for coordination revealed no changes in either treated or control rats. Analytical determinations demonstrated platinum accumulation in the DRG of CDDP treated rats. Spontaneous recovery, demonstrated by morphometric, electrophysiological, functional and analytical determinations, occurred after treatment discontinuation within about 7 weeks. A pilot study of the possible neuroprotective action of retinoic acid (RA) was also performed with this model of cisplatin neuronopathy. The rationale for using RA was based on its assumed antioxidant and neurotrophic effect. However, RA failed to prevent morphometric, electrophysiological, functional and analytical alterations induced by CDDP on DRG neurons. RA induced only a mild generalized prot...Continue Reading

Citations

Jun 17, 2005·Journal of the Peripheral Nervous System : JPNS·Giuseppe LauriaGuido Cavaletti
Feb 24, 2018·Pharmacological Reports : PR·Anil KumarArti Singh
Dec 11, 1999·Current Opinion in Neurology·A J Windebank
Jan 14, 2004·Proceedings of the National Academy of Sciences of the United States of America·Roberto BianchiPietro Ghezzi
Oct 1, 2009·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Nicolas AuthierAlain Eschalier
Feb 10, 2017·Scientific Reports·Shih-Tien HsuYueh-Sheng Chen
Dec 25, 2009·Fundamental & Clinical Pharmacology·Amteshwar Singh JaggiNirmal Singh
Mar 4, 2015·Laboratory Animals·H Naji-EsfahaniM Rafieian-Kopaei
Apr 2, 2009·Journal of the Peripheral Nervous System : JPNS·Ilaria RoglioRoberto C Melcangi
Apr 8, 2016·Current Opinion in Supportive and Palliative Care·Holly L HopkinsSarah J L Flatters
Jul 16, 2010·Journal of the Peripheral Nervous System : JPNS·Annalisa CantaGuido Cavaletti
Apr 28, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Roberto BianchiGuido Cavaletti
Oct 24, 2020·International Journal of Molecular Sciences·Jelena S Katanic StankovicGvozden Rosic
Mar 13, 2021·Progress in Neurobiology·Rabia Bouali-BenazzouzPascal Fossat
Sep 29, 2011·Neuroscience·M PesaresiR C Melcangi

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