PMID: 9539367Apr 16, 1998Paper

Experimental Clostridium perfringens type D enterotoxemia in goats

Veterinary Pathology
F A Uzal, W R Kelly

Abstract

The effects of intraduodenal administration of Clostridium perfringens cultures and culture products in goats were evaluated to develop a reliable experimental model of enterotoxemia in this species. Five conventionally reared, 11-16-week-old Angora goat kids were dosed intraduodenally with whole cultures of C. perfringens type D; five similar animals were dosed with C. perfringens type D filtered culture supernatant; and a third group of five kids was dosed with C. perfringens type D washed cells. Two kids were used as controls and received sterile, nontoxic culture medium intraduodenally. All animals received starch solution into the abomasum. All five kids inoculated with whole culture and three of five dosed with culture supernatant and with washed cells developed central nervous system signs. Diarrhea was observed in two of five kids inoculated with whole culture, in all five of those dosed with culture supernatant, and in three of five of those that received washed cells. The most striking postmortem findings consisted of lung edema, necrotizing pseudomembranous colitis, and cerebral vasogenic edema. The protocol thus provided a reasonable model of naturally occurring enterotoxemia in goats, producing a range of clinical ...Continue Reading

References

Mar 18, 1978·The Veterinary Record·D BuxtonD A Dyson
Jan 1, 1996·Veterinary Research Communications·F A Uzal, W R Kelly
Aug 30, 1997·The Veterinary Record·F A UzalR Thomas

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Citations

Feb 13, 2003·Comparative Immunology, Microbiology and Infectious Diseases·Gianfranco DonelliRichard W Titball
Aug 5, 2009·Infection and Immunity·Martina ChiarezzaJulian I Rood
Jun 15, 2007·Infection and Immunity·Mariano E Fernandez-MiyakawaFrancisco A Uzal
Aug 28, 2012·Computational and Mathematical Methods in Medicine·Tianchan NiuDavid M Hartley
Sep 19, 2009·PloS One·Jorge GoldsteinMariano E Fernandez Miyakawa
Dec 20, 2011·Anaerobe·Winston E MorrisMariano E Fernandez-Miyakawa
May 4, 2011·The FEBS Journal·Michel R Popoff
Jan 30, 2002·Journal of Comparative Pathology·F A UzalR A Assis
May 2, 2013·Toxicon : Official Journal of the International Society on Toxinology·Laetitia WiolandBernard Poulain
Jun 25, 2013·Comparative Immunology, Microbiology and Infectious Diseases·Janneke G AllaartAndrea Gröne
Oct 6, 2004·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·F A UzalM Baisón
Mar 29, 2003·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·F A UzalF Galea
May 8, 2008·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Francisco A Uzal, J Glenn Songer
Jan 22, 2019·Veterinary Pathology·Joaquín OrtegaFrancisco A Uzal
Oct 3, 2002·Equine Veterinary Journal·K A MayR L Pyle
Jun 9, 2018·Anaerobe·Francisco A UzalBruce A McClane

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