Experimental co-infections of domestic ducks with a virulent Newcastle disease virus and low or highly pathogenic avian influenza viruses

Veterinary Microbiology
Mary Pantin-JackwoodDavid E Swayne

Abstract

Infections with avian influenza viruses (AIV) of low and high pathogenicity (LP and HP) and Newcastle disease virus (NDV) are commonly reported in domestic ducks in many parts of the world. However, it is not clear if co-infections with these viruses affect the severity of the diseases they produce, the amount of virus shed, and transmission of the viruses. In this study we infected domestic ducks with a virulent NDV virus (vNDV) and either a LPAIV or a HPAIV by giving the viruses individually, simultaneously, or sequentially two days apart. No clinical signs were observed in ducks infected or co-infected with vNDV and LPAIV, but co-infection decreased the number of ducks shedding vNDV and the amount of virus shed (P<0.01) at 4 days post inoculation (dpi). Co-infection did not affect the number of birds shedding LPAIV, but more LPAIV was shed at 2 dpi (P<0.0001) from ducks inoculated with only LPAIV compared to ducks co-infected with vNDV. Ducks that received the HPAIV with the vNDV simultaneously survived fewer days (P<0.05) compared to the ducks that received the vNDV two days before the HPAIV. Co-infection also reduced transmission of vNDV to naïve contact ducks housed with the inoculated ducks. In conclusion, domestic ducks...Continue Reading

References

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Citations

May 7, 2015·The Journal of Infectious Diseases·Stacey Schultz-Cherry
Apr 19, 2017·Avian Pathology : Journal of the W.V.P.A·Francesco BonfanteCalogero Terregino
Jul 7, 2018·Clinical Microbiology Reviews·Naveen KumarBarry T Rouse
Sep 21, 2018·Veterinary Research·Zaib Ur RehmanMuhammad Munir
Sep 4, 2020·PLoS Pathogens·Axel O G HoarauCamille Lebarbenchon
Apr 6, 2019·Infectious Disorders Drug Targets·Imre Kovesdi, Tibor Bakacs
Sep 24, 2021·The Journal of Antimicrobial Chemotherapy·Sweta ChekuriSarah W Baron

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