Experimental colitis in mice is attenuated by topical administration of chlorogenic acid

Naunyn-Schmiedeberg's Archives of Pharmacology
Hubert ZatorskiJ Fichna

Abstract

Epidemiological data suggest that the consumption of polyphenol-rich foods reduces the incidence of cancer, coronary heart disease, and inflammation. Chlorogenic acid (CGA), an ester of caffeic and quinic acids, is one of the most abundant polyphenol compounds in human diet with proven biological effectiveness both in vitro and in vivo. The aim of the study is to investigate the possible anti-inflammatory effect of CGA in the gastrointestinal (GI) tract and its mechanism of action. We used a well-established model of colitis, induced by intracolonic (i.c.) administration of trinitrobenzenesulfonic acid (TNBS) in mice. The anti-inflammatory effect of CGA in the colon was evaluated based on the clinical and macroscopic and microscopic parameters. To investigate the mechanism of protective action of CGA, myeloperoxidase (MPO), H2O2, and NF-κB levels were assessed in the colon tissue. CGA administered i.c. at the dose of 20 mg/kg (two times daily) protected against TNBS-induced colitis more effectively than the same dose administered orally (p.o.), as evidenced by significantly lower macroscopic and ulcer scores. Furthermore, CGA (20 mg/kg, i.c.) reduced neutrophil infiltration, as demonstrated by decreased MPO activity. Moreover, ...Continue Reading

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Citations

Mar 14, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hyung-Jae ChoiSeung-Sik Cho
Sep 8, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Seung-Hui SongSeung-Sik Cho
Mar 22, 2019·Molecular and Cellular Biochemistry·Ningjian LiangDavid D Kitts
Jul 31, 2019·Naunyn-Schmiedeberg's Archives of Pharmacology·Hubert ZatorskiJakub Fichna
Jan 15, 2021·Comprehensive Reviews in Food Science and Food Safety·William LeonardZhongxiang Fang
Jul 28, 2020·Life Sciences·Roberto de Paula do NascimentoMario Roberto Maróstica Junior
Sep 19, 2021·Pharmacological Reports : PR·Hubert ZatorskiJakub Fichna
Nov 27, 2021·Phytotherapy Research : PTR·Fahimeh Zamani-GarmsiriReza Meshkani

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Methods Mentioned

BETA
Assay
bronchoalveolar lavage

Software Mentioned

GelProAnalyzer
MoticImages Plus
GraphPad
Prism

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