Experimental colonization of the canine urinary tract with the asymptomatic bacteriuria Escherichia coli strain 83972

Veterinary Microbiology
Mary F ThompsonDarren J Trott

Abstract

Establishment of asymptomatic bacteriuria (ABU) with Escherichia coli 83972 is a viable prophylactic alternative to antibiotic therapy for the prevention of recurrent bacterial urinary tract infection in humans. Approximately 2 × 10(8) viable E. coli 83972 cells were introduced into the bladder of six healthy female dogs via a sterile urinary catheter. The presence of pyuria, depression, stranguria, pollakiuria and haematuria was documented for 6 weeks and urinalysis and aerobic bacterial cultures were performed every 24-72 h. Pyuria was present in all dogs on day 1 post-inoculation and 4/6 dogs (67%) had a positive urine culture on this day. Duration of colonization ranged from 0 to 10 days (median 4 days). Four dogs were re-inoculated on day 20. Duration of colonization following the second inoculation ranged from 1 to 3 days. No dog suffered pyrexia or appeared systemically unwell but all dogs initially exhibited mild pollakiuria and a small number displayed gross haematuria and/or stranguria. By day 3 of each trial all clinical signs had resolved. Persistent bacteriuria was not achieved in any dog but two dogs were colonized for 10 days following a single inoculation. Further research is required to determine whether establ...Continue Reading

References

Dec 6, 2000·Journal of the American Animal Hospital Association·C R NorrisA L Ruby
Oct 19, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Rabih O DarouicheRichard A Hull
Jul 24, 2008·Journal of Veterinary Internal Medicine·J S GibsonD J Trott

❮ Previous
Next ❯

Citations

Jan 9, 2014·The Journal of Antimicrobial Chemotherapy·Sam AbrahamDarren J Trott
Apr 13, 2011·The Veterinary Journal·Thurid Freitag
Jan 18, 2011·The Veterinary Journal·Mary F ThompsonDarren J Trott
Oct 12, 2019·Journal of Feline Medicine and Surgery·Roswitha DorschHeidi Sjetne Lund
Jan 18, 2013·Journal of the American Animal Hospital Association·Nicole SmeeGregory F Grauer
Feb 16, 2019·Journal of Veterinary Internal Medicine·Anaïs LamoureuxChristelle Maurey
Nov 14, 2012·Journal of the American Animal Hospital Association·Nicole SmeeGreg Grauer
May 26, 2017·PloS One·Erin N BurtonAaron C Ericsson
Nov 15, 2021·Australian Veterinary Journal·H Teh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bladder Carcinoma In Situ

Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.