Experimental correlation between T2* and ultimate compressive strength in lumbar porcine vertebrae

Academic Radiology
T B BrismarH Ringertz

Abstract

The authors used magnetic resonance (MR) imaging to investigate the correlation between T2* measurements of trabecular bone and the ultimate compressive strength of lumbar porcine vertebrae. Five pigs that weighted 25-32 kg were sacrificed and imaged with a 1.5-T MR system. T2* of the lumbar vertebrae was measured from gradient-echo images. The vertebrae were individually compressed at a fixed speed in the direction of the spine until crushed. The maximum load a vertebra could resist was recorded. T2* ranged from 7.1 to 14.5 msec. T2* determined from 5-mm coronal sections differed from that determined from axial and sagittal sections (P < .05). Between 2.9 and 5.4 kN of force (296-550 kg) was needed to crush a vertebra. A linear correlation between the ultimate compressive strength and T2* of all vertebrae was observed for all imaging planes and section thicknesses (P < .001, except for 10-mm sagittal images, for which P < .002). The T2* determined for the axial plane showed the best correlation with the ultimate compressive strength (r = -0.83). The correlation between T2* values and vertebral strength indicates that MR imaging may potentially be used to predict fracture risks in patients.

References

Nov 1, 1991·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S MajumdarH K Genant
Jun 1, 1991·Radiology·F W WehrliF S Kaplan
Mar 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·D Kirk
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Nov 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·H ChungS D Kugelmass

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Citations

Dec 5, 2002·Topics in Magnetic Resonance Imaging : TMRI·Sharmila Majumdar
Jan 22, 2013·The Spine Journal : Official Journal of the North American Spine Society·Juho-Antti JunnoJuha Tuukkanen
Aug 6, 2003·Radiologic Clinics of North America·Thomas M Link, Sharmila Majumdar
Aug 4, 2001·Best Practice & Research. Clinical Rheumatology·K G Faulkner, N Pocock
Nov 1, 2006·NMR in Biomedicine·Felix W WehrliAlexander C Wright
Nov 18, 2006·Physics in Medicine and Biology·E LammentaustaM T Nieminen
Nov 5, 2016·Physics in Medicine and Biology·Markus KraigerRudolf Stollberger

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