Experimental demonstration of the existence of highly permeable localized transport regions in low-frequency sonophoresis

Journal of Pharmaceutical Sciences
Joseph KushnerRobert Langer

Abstract

Recent advances in low-frequency sonophoresis have focused on the existence of hypothesized localized transport regions (LTRs). However, there has been no actual experimental demonstration that the hypothesized LTRs are, in fact, localized regions of high permeability. Through a series of low-frequency sonophoresis experiments conducted with full-thickness pig skin, in the presence of the surfactant sodium lauryl sulfate (SLS), in which we have separately measured the transport of calcein through the LTRs, which have areas ranging from 10 to 40 mm(2), and the surrounding regions of the skin (the non-LTRs) by means of a novel masking technique, we demonstrate that the calcein permeability through the LTRs is approximately 80-fold higher than the calcein permeability through the non-LTRs, suggesting that the LTRs are structurally perturbed to a greater extent than the non-LTRs from the exposure to the ultrasound/SLS system. In addition, we propose basic models to predict the total skin transdermal permeability from the transdermal permeabilities of the LTRs and the non-LTRs, and then compare the predictions to the experimental data obtained from the masking experiments. We also demonstrate that both the LTRs and the non-LTRs exhi...Continue Reading

References

Nov 1, 1988·Journal of Oral Pathology·C A Squier, C A Lesch
Jun 1, 1980·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M K Nemanic, P M Elias
Jul 17, 1995·Biochemical and Biophysical Research Communications·T E ZewertJ C Weaver
Sep 1, 1994·Journal of Pharmaceutical Sciences·D A Edwards, R Langer
Jul 1, 1996·Journal of Pharmaceutical Sciences·M E JohnsonR Langer
Dec 1, 1996·Journal of Pharmaceutical Sciences·M R PrausnitzC Cullander
Aug 4, 1998·Journal of Pharmaceutical Sciences·S HenryM R Prausnitz
Sep 2, 1998·Journal of Pharmaceutical Sciences·M SznitowskaA C Williams
Jan 26, 1999·Annals of the New York Academy of Sciences·V P Zharov, A S Latyshev
Jun 17, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·R VanbeverJ C Weaver
Jun 17, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·T R GowrishankarJ C Weaver
Jun 29, 2001·The Journal of Pharmacy and Pharmacology·C CurdyR H Guy
Jan 10, 2002·Journal of Pharmaceutical Sciences·Ahmet TezelSamir Mitragotri
Dec 18, 2002·Journal of Pharmaceutical Sciences·Charu Kochhar, Georgios Imanidis
Feb 27, 2003·The Journal of Investigative Dermatology·Betty YuRobert Langer
May 23, 2003·Journal of Pharmaceutical Sciences·R Alvarez-RománR H Guy
Nov 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Devin V McAllisterMark R Prausnitz

❮ Previous
Next ❯

Citations

Jan 13, 2011·The Journal of Physical Chemistry. B·Baris E PolatDaniel Blankschtein
Jan 28, 2014·Advanced Drug Delivery Reviews·Aharon AzaguryJoseph Kost
May 15, 2012·Advanced Drug Delivery Reviews·Longjian ChenGuoping Lian
Oct 8, 2014·Therapeutic Delivery·Matthias A OberliDaniel Blankschtein
Sep 27, 2008·Expert Opinion on Drug Delivery·Nadine Barrie Smith
Dec 2, 2010·Expert Opinion on Drug Delivery·Baris E PolatRobert Langer
Feb 2, 2008·Journal of Pharmaceutical Sciences·Joseph KushnerRobert Langer
Feb 11, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Carl M SchoellhammerDaniel Blankschtein
Nov 9, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jennifer E SetoDaniel Blankschtein
Jan 18, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Baris E PolatDaniel Blankschtein
Jul 27, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Lior Wolloch, Joseph Kost
May 3, 2008·Advanced Drug Delivery Reviews·Makoto OguraSamir Mitragotri
Jan 2, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ilana LavonGiora Enden
Sep 17, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ilana LavonJoseph Kost
Nov 22, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Baris E PolatDaniel Blankschtein
Mar 14, 2017·Scientific Reports·Tatiana Aparecida PereiraRenata F V Lopez
Oct 30, 2020·International Journal of Nanomedicine·Yugo A MartinsRenata F V Lopez
Jul 27, 2021·Ultrasound in Medicine & Biology·Lixia Mei, Zhen Zhang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.