Experimental Demyelination and Remyelination of Murine Spinal Cord by Focal Injection of Lysolecithin

Methods in Molecular Biology
Chenyi Wang, Mark R Kotter

Abstract

Multiple sclerosis (MS) is a chronic autoimmune, inflammatory disease in the central nervous system (CNS) characterized by loss of oligodendrocytes, myelin axons, and neurons. Remyelination is an endogenous repair mechanism, which recovers the loss of myelin and is able to preserve functional axons. The hope is that the development of new treatments aiming at promoting remyelination will halt and potentially partially reverse the progressive neurological decline in MS. The development of such drugs requires adequate models. In this chapter, we will discuss the surgical procedure of injection of lysolecithin into ventral thoraco-lumbar spinal cord white matter of mice, which is particularly suitable for investigating remyelination using transgenic animals.

Citations

Jan 10, 2019·International Journal of Molecular Sciences·Stefanie ScheuJudith Alferink
Feb 23, 2020·The Journal of Experimental Medicine·Maria Inês CunhaMikael Simons
Jun 9, 2020·Molecular Neurobiology·Alice Grison, Suzana Atanasoski

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