Experimental determination of the diffusion boundary layer width of micron and submicron particles

International Journal of Pharmaceutics
C Galli

Abstract

Powder dissolution kinetics have shown that for particles in the so called "large" size regime (more than about 50 microm), the dissolution rate scales as the specific surface area, i.e. rate proportional to d(-1) where d is the particle diameter. This is consistent with an effective diffusion boundary layer width h(EFF) that is constant with respect to particle size. However, for particles in the so called "small" size regime (d less than about 50 microm), the dissolution rate has a stronger dependence than proportional to d(-1) [Bisrat, M., Anderberg, E.K., Barnett, M.I., Nystroem, C., 1992. Physicochemical aspects of drug release. XV. Investigation of diffusional transport in dissolution of suspended, sparingly soluble drugs. Int. J. Pharm., 80, 191-201; Mosharraf, M., Nystroem, C., 1995. The effect of particle size and shape on the surface specific dissolution rate of microsized practically insoluble drugs. Int. J. Pharm., 122, 35-47]. In this regime, Prandtl boundary layer theory predicts an h(EFF) approximately equal to the particle radius or diameter. This paper presents the first experimental determination of h(EFF) for particles less than about 2 microm. The powder dissolution kinetics of six suspensions over the parti...Continue Reading

Citations

Jun 13, 2012·Pharmaceutical Research·Katharina AnhaltGert Fricker
Jun 12, 2013·International Journal of Pharmaceutics·Chris Brough, R O Williams
Jul 1, 2010·Therapeutic Delivery·Evren H GokceEliana B Souto
Jul 9, 2013·International Journal of Pharmaceutics·May S FreagOssama Y Abdallah
Apr 1, 2009·Expert Opinion on Drug Metabolism & Toxicology·Kiyohiko Sugano
Oct 25, 2014·Drug Development and Industrial Pharmacy·Shashank JainSenshang Lin
May 20, 2015·Journal of Pharmaceutical Sciences·Lennart LindforsBertil Abrahamsson
Oct 21, 2014·Environmental Microbiology·Christian Dusny, Andreas Schmid
Apr 20, 2016·International Journal of Pharmaceutics·Ramona BaumgartnerEva Roblegg
Jan 29, 2011·International Journal of Pharmaceutics·Puneet SharmaSanjay Garg
May 8, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Stefan Horkovics-Kovats
Jan 25, 2017·Drug Delivery and Translational Research·Sanyog JainChander Parkash Dora
Nov 26, 2009·Chemistry & Biodiversity·Alex AvdeefDmytro Voloboy
Dec 1, 2020·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Philip da IgrejaMarkus Thommes
Sep 9, 2020·International Journal of Pharmaceutics·Tingting ChenQingguo Li
Jun 19, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Desmond HengJudy A Raper

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
Elaine Merisko-LiversidgeEugene R Cooper
European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
Cornelia M Keck, Rainer H Müller
© 2021 Meta ULC. All rights reserved