PMID: 525Jun 1, 1975

Experimental diarrhea in cynomolgus monkeys by oral administration with Clostridium perfringens type A viable cells or enterotoxin

Japanese Journal of Medical Science & Biology
T UemuraS Sakai


Purified C. perfringens type A enterotoxin fed orally in an amount of 5 mg caused both vomiting and diarrhea in the monkey only when the gastric juice had been neutralized. Exposure of enterotoxin to pH 4.0 or below rapidly destroyed the activity. All three monkeys receiving sodium bicarbonate and 2.4 X 10(10) viable cells grown in DS medium developed diarrhea, and only one of them vomited once. The diarrhea lasted for 13, 18 and 19 hr. The symptoms were similar to those reported in human cases of C. perfringens food poisoning. These results have verified the general notion that C. perfringens food poisoning should be categorized as a true "intravital intoxication". The reversed passive hemagglutination test detected enterotoxin directly in most fecal samples. This method may be applicable for diagnosis of human cases of C. perfringens food poisoning. Neither enterotoxin nor anti-enterotoxin was detected in serum samples taken from any monkey up to 21 days after the challenge. We are tempted to conclude, therefore, that no significant amount of C. perfringens enterotoxin is absorbed from the intestine.


Aug 1, 1966·The Journal of Applied Bacteriology·R A Groom, D H Strong
Aug 1, 1967·Canadian Journal of Microbiology·A H HauschildF S Thatcher
Jul 1, 1969·Canadian Journal of Microbiology·C L Duncan, D H Strong
May 1, 1970·Canadian Journal of Microbiology·A H HauschildW J Dorward
Jul 1, 1971·Canadian Journal of Microbiology·A H HauschildW J Dorward
Aug 1, 1971·Canadian Journal of Microbiology·A H HauschildW Campbell
Nov 1, 1971·Canadian Journal of Microbiology·A H Hauschild, R Hilsheimer
Feb 1, 1974·Infection and Immunity·T UemuraC E Franti


Jun 1, 1977·The Journal of Applied Bacteriology·R Skjelkvålé, T Uemura
Jan 1, 1980·Pharmacology & Therapeutics·J L McDonel
May 1, 1986·The British Veterinary Journal·T FukataA Arakawa
Oct 1, 1977·The Journal of Applied Bacteriology·R Skjelkvålé, T Uemura
Dec 1, 1976·Acta Pathologica Et Microbiologica Scandinavica. Section B, Microbiology·T Uemura, R Skjelkvålé

Related Concepts

Clostridium perfringens
Gastric Juice
Hydrogen-Ion Concentration
Macaca fascicularis

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