Experimental disc herniation: evaluation of the natural course

Spine
K OtaniS Kikuchi

Abstract

Changes in L7 nerve root conduction velocity and changes in appearance on magnetic resonance study of the L6-L7 intervertebral disc in the dog were assessed for 2-6 months after an experimental disc herniation was performed. To assess the time-related changes of nerve conduction velocity and magnetic resonance changes of the intervertebral discs. It is known that nucleus pulposus may induce nerve root morphologic and functional changes when applied epidurally. However, it is not known whether such changes are reversible. The spinal canal was opened by laminotomy of the upper part of the L7 lamina and the lower part of the L6 lamina on the left side. The L7 nerve root was gently retracted (sham) or the disc was punctured and injected with saline to produce herniation of the nucleus pulposus during the retraction time (herniation). After 1 day to 2 months, nerve root conduction velocity was determined by local electrical stimulation. Six dogs had the herniation or the sham procedure, and the L6-L7 disc was studied by magnetic resonance imaging at various times up to 6 months after the procedure. Decrease in nerve conduction velocity reached a maximum after 7 days and recovered to baseline level fully within 2 months. Although the...Continue Reading

References

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Citations

Jun 24, 2011·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Kazuhide UesugiShin-ichi Konno
Aug 19, 2004·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Itaru AraiK Olmarker
May 18, 2000·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·M KawakamiT Kihira
Apr 30, 2003·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Gabriela SeilerJohann Lang
Dec 8, 2004·Biological Research for Nursing·Angela StarkweatherHerbert L Mathews
Feb 24, 2001·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·G ByrödK Olmarker
Sep 12, 2006·Pain·Baogan PengXiaoning Wang
Aug 15, 2013·Pain Practice : the Official Journal of World Institute of Pain·Jan Willem KallewaardGerbrand Jan Groen
Nov 1, 2010·Revista Brasileira De Ortopedia·André Luiz de Souza GravaHelton Luiz Aparecido Defino
Oct 4, 2020·Pediatric Blood & Cancer·Yoshiko OshiroThomas E Merchant
Dec 5, 2006·Journal of Manipulative and Physiological Therapeutics·Gregory CramerJoel Pickar

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