Experimental Escherichia coli ascending pyelonephritis in rats: active peroral immunization with live Escherichia coli.

Infection and Immunity
I Mattsby-BaltzerB Kaijser

Abstract

Peroral immunization with a live strain of Escherichia coli O6K13H1 against experimental ascending pyelonephritis caused by the same strain was studied in rats, and the effect of immunization on antibody titers against the O and K antigens and lipid A was determined. Peroral immunization with live bacteria protected significantly against pyelonephritis. Sera collected 1 week after infection from the immunized group were increased in immunoglobulin G (IgG) anti-O6 and IgM anti-K13 in comparison with the nonimmunized group. The peroral immunization did not correspondingly affect the response to lipid A. In urine, there was an IgG antibody response to the O6 antigen. In bronchopulmonary secretion, IgM, IgG, and IgA antibodies to O6 were detected. Perorally immunized animals had significantly higher levels of IgG and IgA anti-O6 compared with the nonimmunized group 1 week after infection. Passive transfer of anti-lipid A did not increase resistance against pyelonephritis.

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Citations

Apr 1, 1985·Scandinavian Journal of Immunology·C Svanborg EdénJ Mestecky
Oct 1, 1992·Immunology and Cell Biology·V L CliftonD J Kay
Jun 30, 1983·Annals of the New York Academy of Sciences·R J GencoR T Evans
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May 15, 1984·The American Journal of Medicine·J D Sobel, D Kaye
Apr 1, 1987·American Journal of Surgery·D L Dunn
Dec 10, 1999·The Urologic Clinics of North America·D E Neal

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