Experimental evaluation of anti-inflammatory, antinociceptive and antipyretic activities of clove oil in mice

The Libyan Journal of Medicine
Yousef A TaherHanan A Salem

Abstract

Clove oil of Eugenia caryophyllata (Myrtaceae) is a light yellowish fluid obtained from dried flower buds. Clove oil is used traditionally to relieve toothache. The aim of the present work was to study the anti-inflammatory, antinociceptive and antipyretic potential of clove oil in mice. Analgesic activity was examined using acetic-acid-induced abdominal constrictions and the hot plate test. Carrageenan-induced paw edema and brewer's-yeast-induced pyrexia were used to investigate the anti-inflammatory activity and the antipyretic effects, respectively. The oil was administered intraperitoneally (i.p.) at a dose of 33 mg/kg body weight and the effects were compared with reference drugs. In the antinociceptive test, mice treated with clove oil exhibited significantly decreased acetic-acid-induced writhing movements by a maximum of 87.7% (p<0.01) compared with a decrease of 77.7% (p<0.01) in response to aspirin injection (100 mg/kg, intraperitoneal, i.p.). Similarly, in the hot plate test, clove oil significantly increased the reaction latency to pain after 60 min by 82.3% (p<0.05) compared with morphine value of 91.7% (p<0.01). In addition, clove oil and indomethacin produced anti-inflammatory effects, as demonstrated by respecti...Continue Reading

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Citations

Sep 13, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jian-Guo XuXin-Ming Cao
Jul 1, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rahul ChandranHeidi Abrahamse
Jul 24, 2020·Animals : an Open Access Journal From MDPI·Sandra FrahmSusanne Waiblinger
Nov 15, 2018·Oxidative Medicine and Cellular Longevity·Joice Nascimento BarbozaDamião Pergentino de Sousa
Aug 2, 2020·Drug Development Research·Olga Edith González-LugoAngel Antonio Vértiz-Hernández
Mar 23, 2021·International Journal of Food Science·Novi SafrianiEndang Prangdimurti

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BETA
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GraphPad Prism

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