PMID: 6986189Jan 1, 1980Paper

Experimental evaluation of local anaesthetic solutions using rat infraorbital nerve block

Canadian Anaesthetists' Society Journal
L B Ready, B R Fink

Abstract

The analgesic effectiveness of various local anaesthetic solutions was measured in the distribution of the infraorbital nerve of the rat. Using Sprague-Dawley rats sedated with phenobarbitone 25 mg/kg intraperitoneally and a simple stereotactic technique, 0.2 ml of solution was deposited at the infraorbital notch. The onset and duration of analgesia were ascertained by timing the unilateral absence of aversive response to pinching the upper lip, tested at intervals of five minutes. The experiments were performed with coded solutions, the entire code being preserved intact until completion of the study. Solutions were tested on sets of eight animals weighing 500--600 g. The average duration (minutes +/- S.D.) of analgesia produced by the respective injectates was as follows: Lidocaine 0.5% -42+/-12 Lidocaine 1.0% -47+/-10 Mepivacaine 0.5% -58+/-13 Mepivacaine 1.0% -78+/-23 Procaine 0.5% -0+/-0 Procaine 1.0% -34+/-10 Procaine 1.5% -46+/-13 2-Chloroprocaine 1.5% -38+/-9 Bupivacaine 0.5% -100+/-40 Etidocaine 1.0% -59+/-25 Tetracaine 0.2% -0+/-0 Tetracaine 0.3% -0+/-0 Comparison with other animal models used to evaluate conduction block indicates that this technique affords an improved, standardized and reliable experimental guide t...Continue Reading

References

Jan 1, 1957·Anesthesiology·J J BONICA
Feb 1, 1961·British Journal of Pharmacology and Chemotherapy·A ASTROM, N H PERSSON
Jan 1, 1961·Acta Anaesthesiologica Scandinavica·J ALBERT, B LOFSTROM
Mar 1, 1951·Journal of the American Pharmaceutical Association·F P LUDUENA, J O HOPPE

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Citations

Nov 3, 2006·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Cíntia Maria Saia CeredaEneida de Paula
Nov 4, 2011·Journal of Drug Targeting·Roberta Aline Franco de LimaEneida de Paula
May 1, 1985·Acta Anaesthesiologica Scandinavica·H G HassanB Lindquist
Jul 1, 1994·Acta Anaesthesiologica Scandinavica·H G HassanH Youssef

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