Experimental evaluation of the spasmogenicity of dopamine on the basilar artery

Journal of Neurosurgery
R P WhiteJ T Robertson

Abstract

Arteriograms of the basilar artery reveal that dopamine given intracisternally to dogs can generate cerebral vasospasm. This finding supports a recent hypothesis of others that dopamine may play a role in the pathogenesis of vasospasm, especially since many substances are known which fail to produce such spasm. Compared to blood or prostaglandin E2, however, the spasm induced by dopamine was delayed in onset, less in incidence, and usually less intense. Possible explanations for such experimental differences are discussed.

References

Jan 1, 1975·Stroke; a Journal of Cerebral Circulation·R P WhiteJ T Robertson
Jul 1, 1974·Annals of the Rheumatic Diseases·C DavidsonP A Bacon
Apr 1, 1974·Journal of Neurosurgery·J L Wilson, J R Feild
Jan 1, 1972·Stroke; a Journal of Cerebral Circulation·A KuwayamaK S Pickren
Jan 1, 1968·Journal of Neurosurgery·B W BrawleyW A Kelly
Jan 1, 1957·Journal of Neurophysiology·H E HIMWICH, R P WHITE
Jun 1, 1957·The American Journal of Physiology·R P White, H E HIMWICH

Citations

Apr 1, 1989·Molecular and Chemical Neuropathology·H Z TangY Q Huang
Jan 13, 1984·European Journal of Pharmacology·F AmentaM C Mione
Jul 20, 1984·European Journal of Pharmacology·G A LambertJ W Lance
Nov 1, 1978·Acta Physiologica Scandinavica·L EdvinssonC Owman
Oct 1, 1978·Journal of Neurosurgery·F D BrownS Mullan
Feb 1, 1979·Journal of Neurosurgery·R P WhiteJ T Robertson
Aug 1, 1979·Journal of Neurosurgery·R P WhiteJ T Robertson
Dec 1, 1982·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J McCullochI Ford
Jul 31, 2003·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Kevin A Strauss, D Holmes Morton
Oct 1, 1990·Stroke; a Journal of Cerebral Circulation·L K StruckJ K Dobson
Jul 1, 1985·Stroke; a Journal of Cerebral Circulation·T J DelgadoN A Svendgaard

Related Concepts

Structure of Basilar Artery
Blood
Diastolic Blood Pressure
Crescendo Transient Ischemic Attacks
Canis familiaris
Intropin
Dose-Response Relationship, Drug
Hydrogen-Ion Concentration
Injections, Intraventricular
Prostaglandins E

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