Experimental Evidence and Clinical Implications of Pituitary Adenoma Stem Cells.

Frontiers in Endocrinology
Roberto WürthTullio Florio

Abstract

Pituitary adenomas, accounting for 15% of diagnosed intracranial neoplasms, are usually benign and pharmacologically and surgically treatable; however, the critical location, mass effects and hormone hypersecretion sustain their significant morbidity. Approximately 35% of pituitary tumors show a less benign course since they are highly proliferative and invasive, poorly resectable, and likely recurring. The latest WHO classification of pituitary tumors includes pituitary transcription factor assessment to determine adenohypophysis cell lineages and accurate designation of adenomas, nevertheless little is known about molecular and cellular pathways which contribute to pituitary tumorigenesis. In malignant tumors the identification of cancer stem cells radically changed the concepts of both tumorigenesis and pharmacological approaches. Cancer stem cells are defined as a subset of undifferentiated transformed cells from which the bulk of cancer cells populating a tumor mass is generated. These cells are able to self-renew, promoting tumor progression and recurrence of malignant tumors, also conferring cytotoxic drug resistance. On the other hand, the existence of stem cells within benign tumors is still debated. The presence of ad...Continue Reading

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Citations

Jun 13, 2020·Frontiers in Endocrinology·Raitis PeculisVita Rovite
Jul 25, 2020·The Journal of Clinical Endocrinology and Metabolism·Kiyohiko SakataMotohiro Morioka
Oct 6, 2020·Frontiers in Endocrinology·Gwen V ChildsMelanie C MacNicol

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Methods Mentioned

BETA
flow cytometry
xenograft
FACS
xenografts

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