Experimental evidence of biological interactions among different isolates of Trypanosoma cruzi from the Chaco Region

PloS One
P G RagonePatricio Diosque

Abstract

Many infectious diseases arise from co-infections or re-infections with more than one genotype of the same pathogen. These mixed infections could alter host fitness, the severity of symptoms, success in pathogen transmission and the epidemiology of the disease. Trypanosoma cruzi, the etiological agent of Chagas disease, exhibits a high biological variability often correlated with its genetic diversity. Here, we developed an experimental approach in order to evaluate biological interaction between three T. cruzi isolates belonging to different Discrete Typing Units (DTUs TcIII, TcV and TcVI). These isolates were obtained from a restricted geographical area in the Chaco Region. Different mixed infections involving combinations of two isolates (TcIII + TcV, TcIII + TcVI and TcV + TcVI) were studied in a mouse model. The parameters evaluated were number of parasites circulating in peripheral blood, histopathology and genetic characterization of each DTU in different tissues by DNA hybridization probes. We found a predominance of TcVI isolate in blood and tissues respect to TcIII and TcV; and a decrease of the inflammatory response in heart when the damage of mice infected with TcVI and TcIII + TcVI mixture were compared. In additio...Continue Reading

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Citations

Apr 11, 2018·Evolutionary Applications·Alheli Flores-FerrerSébastien Gourbière
Mar 3, 2020·Frontiers in Cellular and Infection Microbiology·Bruno Carvalho ResendeCarlos Renato Machado
Feb 4, 2021·Tropical Medicine and Infectious Disease·Eric Dumonteil, Claudia Herrera
Oct 30, 2021·Frontiers in Cellular and Infection Microbiology·Jose MateusAdriana Cuéllar

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Methods Mentioned

BETA
PCR

Software Mentioned

GraphPad Prism

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