PMID: 9166128Apr 1, 1997Paper

Experimental exposure of male volunteers to N-methyl-2-pyrrolidone (NMP): acute effects and pharmacokinetics of NMP in plasma and urine

Occupational and Environmental Medicine
B Akesson, K Paulsson

Abstract

To study the acute effects of exposure to the increasingly used solvent, N-methyl-2-pyrrolidone (NMP) in male volunteers. Further, to determine the NMP concentration in plasma and urine during and after the exposure. Six male volunteers were exposed for eight hours on four different days to 0, 10, 25, and 50 mg/m3 NMP. Plasma was collected and urine was sampled during and after the exposure. Changes in nasal volume were measured by acoustic rhinometry and in airway resistance by spirometry. The eight-hour experimental exposure to 10, 25, and 50 mg/m3 did not induce discomfort to eyes or upper airways. Acute changes in nasal volume were not found, and no changes in the spirometric data could be registered. The elimination curves suggested a non-linear pattern and at the end of exposure showed mean (range) half lifes of NMP in plasma of about 4.0 (2.9-5.8) hours and in urine 4.5 (3.5-6.6) hours. The unmetabolised NMP found in urine samples collected during exposure and at the subsequent 44 hours corresponded to about 2% of the calculated absorbed dose. At the end of the exposure there was a close correlation between exposures and the plasma concentration and urinary excretion of NMP. NMP was absorbed through the respiratory tract...Continue Reading

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Citations

Dec 20, 2005·International Archives of Occupational and Environmental Health·Michael BaderRenate Wrbitzky
Jun 14, 2005·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Martin A CarnerupBo A G Jönsson
Aug 23, 2002·Toxicology Letters·Peter AkrillSteve Dixon
Oct 12, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·D LigockaV Haufroid
Mar 28, 1998·Journal of Chromatography. B, Biomedical Sciences and Applications·B A Jönsson, B Akesson
Sep 27, 2012·Occupational Medicine·C-C LinP-C Chen
Oct 31, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Torka S PoetPaul M Hinderliter
Apr 5, 2013·International Journal of Environmental Research and Public Health·Ching-Chun LinPau-Chung Chen
Oct 1, 2013·International Archives of Occupational and Environmental Health·Vincent HaufroidPhilipp Hotz
Sep 25, 2014·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·UNKNOWN German Ad-hoc Working Group on indoor Guidelines of the Indoor Air Hygiene Committee and of the States' Supreme Health Autho
Jan 5, 2002·Journal of Toxicology. Clinical Toxicology·I W WuE T Cheng
Feb 9, 2012·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Krystyna SitarekWojciech Wąsowicz
Sep 2, 2015·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·UNKNOWN Bekanntmachung des Umweltbundesamtes
Nov 24, 2005·Cancer Letters·Constance Lay Lay SawPaul Wan Sia Heng
Nov 30, 2006·International Journal of Occupational Medicine and Environmental Health·Krystyna Sitarek, Anna Kilanowicz
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Sep 12, 2009·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Yoshihiro SuzukiNobuhiko Onda
Jul 1, 2017·Environmental Science & Technology·Zhongying Wang, Baoxia Mi
Jul 8, 2005·International Archives of Occupational and Environmental Health·Michael BaderRenate Wrbitzky
Apr 16, 2003·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Jean-Paul PayanJean-Claude André
Nov 16, 2002·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Jean-Paul PayanElisabeth Ferrari
Jul 3, 2021·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Faissal Tarrass, Meryem Benjelloun

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