PMID: 10798652May 8, 2000Paper

Experimental glaucoma and cell size, density, and number in the primate lateral geniculate nucleus

Investigative Ophthalmology & Visual Science
A J WeberPaul L Kaufman


To examine the effects that elevated intraocular pressure (IOP), a glaucoma risk factor, has on the size, density, and number of neurons in the primate lateral geniculate nucleus (LGN). The monkey model of experimental glaucoma was combined with standard histologic staining and analysis techniques. Fourteen animals were examined. Mean IOPs higher than 40 mm Hg for 2.5, 4, 8, and 24 weeks resulted in reductions of 10% to 58% in the cross-sectional areas of LGN neurons receiving input from the glaucomatous eye. Reductions for animals with lower mean IOPs (37 and 28 mm Hg) for 16 and 27 weeks were 16% and 30%, respectively. Neurons receiving input from the normal eye also were reduced in size (4 -26%). No differential effect in cell size was seen for magnocellular versus parvocellular neurons. Elevation of IOP resulted in an increase in cell density in all layers of the LGN. The increase was approximately two times greater in parvocellular (59%) than magnocellular (31%) layers. When corrected for volumetric shrinkage of the LGN, the estimated loss of neurons was approximately four times greater in the magnocellular than parvocellular layers (38% versus 10%). Elevation of IOP affects the size, density, and number of neurons in the ...Continue Reading

Related Concepts

Cell Density
Medial Geniculate Body
Glaucoma, Open-Angle
Physiologic Intraocular Pressure
Macaca fascicularis
Macaca mulatta
Ocular Hypertension
Trabecular Meshwork Structure
Cell Volume

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