PMID: 7030907Nov 1, 1981Paper

Experimental HBV and delta infections of chimpanzees: occurrence and significance of intrahepatic immune complexes of HBcAg and delta antigen

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
M RizzettoJ L Gerin

Abstract

The occurrence and pathogenetic role of intrahepatic deposits of immunoglobulins in experimental viral infection have been evaluated by determining with immunofluorescence their capacity to fix complement in vitro [in vitro complement fixation (VCF)]. Liver biopsies from chimpanzees chronically or acutely infected with hepatitis B virus or the hepatitis B surface antigen (HBsAg)-associated delta agent were used in the study. VCF was observed in each animal expressing hepatitis B core antigen (HBcAg) or delta antigen in the liver and concurrently circulating the homologous antibody in the blood. In acutely infected animals, VCF appeared at the same time that the homologous serum antibody appeared, and the intensity of VCF staining was proportional to the antibody titer in the serum. In animals expressing sequentially the HBcAg/antibody system and then delta antigen and antibody to delta, VCF was first observed in HBcAg-containing nuclei and then in nuclei expressing delta antigen. There was no relationship between VCF and intrahepatic expression of HBsAg or serologic expression of hepatitis B e antigen (HBeAg). A positive VCF reaction appears related to the formation of intrahepatic immune complexes between HBcAg or delta antige...Continue Reading

References

Apr 22, 1976·The New England Journal of Medicine·M A GerberS J Vernace
Jul 1, 1975·The Journal of Investigative Dermatology·D L Tuffanelli
Jun 1, 1973·The Journal of Infectious Diseases·L F BarkerM R Peterson
May 1, 1980·The Journal of Infectious Diseases·M RizzettoR H Purcell

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Citations

Feb 15, 1985·Klinische Wochenschrift·K GmelinF Deinhardt
Nov 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·B BuitragoJ E Maynard
Jan 1, 1984·Journal of Medical Virology·A BudkowskaD Roszuk
Apr 25, 2016·Antiviral Research·Timothy M BlockMike Bray
Oct 11, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Frédéric Le GalEmmanuel Gordien
Sep 1, 1983·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M Rizzetto

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