PMID: 6982715Oct 1, 1982Paper

Experimental hydroxyapatite synovial and articular cartilage calcification: light and electron microscopic studies

Arthritis and Rheumatism
A J ReginatoC T Brighton

Abstract

Intraarticular calciphylaxis with cartilage and synovial calcification was produced in rabbits by oral administration of a single dose of dehydrotachysterol followed by an intraarticular injection of ferrous chloride. Synovial membrane apatite deposits were seen in the interstitium, on collagen fibers, and within cell vacuoles. In contrast, long-term administration of dehydrotachysterol alone induced only articular cartilage calcification. Such calcification was limited to the mid and deep zone of cartilage. Most calcium deposits were apatite-like crystals. Acute crystal-associated inflammation was not demonstrated in these specimens with crystals sequestered in synovial or cartilage tissue. Further studies on these models will examine the relation of apatite to joint disease.

References

Feb 7, 1976·Lancet·P A DieppeD A Willoughby
Mar 13, 1979·Calcified Tissue International·L J MartinoJ J Taylor
Nov 1, 1974·Arthritis and Rheumatism·A J ReginatoV A Martinez
Nov 1, 1972·Arthritis and Rheumatism·C A AgudeloP Phelps
Jun 1, 1962·Arthritis and Rheumatism·H SELYER VEILLEUX
May 27, 1965·The New England Journal of Medicine·J BOCHERG P RODNAN

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Citations

Jan 1, 1989·Virchows Archiv. A, Pathological Anatomy and Histopathology·R LagierJ C Gerster
Jan 1, 1985·Annals of the Rheumatic Diseases·F K Higson, O T Jones
Aug 1, 1985·Annals of the Rheumatic Diseases·A J ReginatoJ L Rabinowitz
Dec 21, 2000·Current Rheumatology Reports·A J ReginatoP Netter
Aug 1, 1983·Annals of the Rheumatic Diseases·H R SchumacherS Rothfuss
Jan 1, 1984·The Journal of Pathology·J McClure
Aug 4, 2011·Rheumatology International·Ana Rita CoutoMatthew A Brown
Nov 1, 1986·Arthritis and Rheumatism·A J ReginatoS Rothfuss

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