PMID: 8949371Aug 1, 1996Paper

Experimental hypertension induced by hypercaloric diet

Archives des maladies du coeur et des vaisseaux
P VerwaerdeJ L Montastruc

Abstract

Obesity, hypertension and hyperinsulinism are frequently related and constitute morbid elements of human athero-thrombogenic syndrom. To elucidate physiopathologic mechanisms linking these symptoms, we have developped an experimental model reproducing the morbid triptyque: obesity-hypertension-insulin resistance were induced by hyperlipidic hypercaloric diet. The aim of this study was to investigate cardiovascular modifications elicited by high fat diet. Four male Beagle-Harrier dogs were used in this preliminary study. We investigated before and 7 weeks after the beginning of the hypercaloric hyperlipidic diet morphologic measures, systemic blood pressure (BP) and heart rate (HR), pulmonary blood pressure, cardiac output (CO), systolic ejection volume (SEV), peripheral arterial resistance (PAR) and HR variability on 24 hours' electrocardiogram obtained by Holter method. Echocardiographic modifications of left ventricule was also studied after 20 weeks. Body weight increased (+15.4%) after 7 weeks and remained stable the whole experimental period. This gain was associated with an increase of thoracic and abdominal circonferences (respectively +5.9% and 14.3% at the 7th week). The abdominal increase was significantly more elevat...Continue Reading

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