PMID: 3758287Oct 1, 1986Paper

Experimental hyperthyroidism stimulates axonal growth in mesothelial chambers

Experimental Neurology
N DanielsenG Lundborg

Abstract

An experimental model is presented for studying axonal growth after experimental hyperthyroidism and hypothyroidism. The left sciatic nerve of the rat was transected and transposed to the back. The proximal nerve stump was inserted into a 50-mm-long mesothelial chamber leaving the distal end of the chamber open. Different groups of young adult rats were given daily injections of thyroxine (10 micrograms/100 g body weight) or the goitrogen, thiamazol, in the drinking water (0.125 g/liter) for 12 weeks. Thyroxine treatment increased significantly the extent of axonal outgrowth from the proximal nerve stump compared with untreated rats. Experimental hypothyroidism (thiamazol treatment), evidenced by a retarded body growth, did not affect the extent of axonal outgrowth. In other experiments the left proximal nerve stump was cross-anastomosed with the right distal nerve stump. The two nerve stumps were bridged with a mesothelial chamber leaving a 15-mm gap. This gap distance is known from our previous studies to inhibit axonal overgrowth to the distal nerve stump. As evidenced by histological evaluation, in three of six thyroxine-treated rats, axons had bridged the 15-mm gap. We conclude that experimentally induced hyperthyroidism e...Continue Reading

References

Apr 1, 1979·Experimental Neurology·M Frizell, W G McLean
Nov 1, 1977·Experimental Neurology·R A BerenbergJ Demaree
Jul 1, 1975·Experimental Neurology·G McIsaac, J A Kiernan
Jan 8, 1985·The Journal of Comparative Neurology·L R Williams, S Varon
Jun 1, 1985·Plastic and Reconstructive Surgery·S E MackinnonD A Hunter
Jul 1, 1981·Experimental Neurology·W H Yu, R Srinivasan
Jan 1, 1983·Scandinavian Journal of Plastic and Reconstructive Surgery·N DanielsenG Lundborg
Dec 1, 1980·Journal of Neurology, Neurosurgery, and Psychiatry·B Rydevik, C Nordborg

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Citations

Sep 1, 2005·Thyroid : Official Journal of the American Thyroid Association·Françoise CourtinMichel Pierre
May 7, 2013·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Rahim MohammadiFarzaneh Abedi
Apr 1, 1987·Acta Orthopaedica Scandinavica·G Lundborg
Jan 1, 1996·Reviews in the Neurosciences·V B DoolabhS E Mackinnon

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