Experimental induction of malignant catarrhal fever in pigs with ovine herpesvirus 2 by intranasal nebulization

Veterinary Microbiology
Hong LiNaomi S Taus

Abstract

Malignant catarrhal fever (MCF), a frequently fatal herpesviral disease primarily of ruminant species, has been sporadically reported in pigs. All cases of naturally occurring porcine MCF reported to date have been linked to ovine herpesvirus 2 (OvHV-2), a gammaherpesvirus in the genus Macavirus carried by sheep. Experimental induction of MCF by aerosolization of the virus in nasal secretions collected from infected sheep has been successful in bison, cattle and rabbits. The goals of this study were to determine the susceptibility of pigs to MCF following experimental intranasal inoculation of OvHV-2, and to characterize the disease. Twelve pigs in four groups were nebulized with 10(5), 10(6), 10(7), or 10(8) DNA copies of OvHV-2 from sheep nasal secretions. Three control pigs were nebulized with nasal secretions from uninfected sheep. Three additional pigs were inoculated intravenously with 10(7) DNA copies of OvHV-2 to evaluate this route of infection with cell-free virus. Seven of twelve intranasally challenged pigs became infected with OvHV-2. Five of these seven, all in higher dose groups, developed MCF. Lesions resembled those reported in natural cases of porcine MCF. The most striking and consistent histological lesions ...Continue Reading

References

Jan 1, 1993·Archives of Virology·S I BaxterH W Reid
Nov 26, 1998·The Veterinary Record·T LøkenI Pow
Aug 2, 2001·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·H LiT B Crawford
Dec 8, 2004·Journal of Clinical Microbiology·Hong LiTimothy B Crawford
Mar 29, 2006·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Hong LiTimothy B Crawford
Jul 5, 2007·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Donald L TraulHong Li
Jun 10, 2008·Veterinary Microbiology·Katherine L GailbreathHong Li
Jun 19, 2008·The Journal of General Virology·Hong LiNaomi S Taus
Mar 17, 2009·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Ana AlcarazHong Li
Dec 3, 2010·Emerging Infectious Diseases·Érica Azevedo CostaRoberto Mauricio Carvalho Guedes
Mar 23, 2011·Veterinary Microbiology·Hong LiNaomi S Taus

❮ Previous
Next ❯

Citations

Aug 6, 2014·Veterinary Microbiology·Kathryn BartleyGeorge C Russell
Nov 11, 2014·Annual Review of Animal Biosciences·Hong LiDonald P Knowles
Jun 17, 2020·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Selwyn Arlington HeadleyCristina Wetzel Cunha
Feb 6, 2017·Transboundary and Emerging Diseases·P H E ArrudaB M Hause
Feb 20, 2021·Frontiers in Veterinary Science·Naveen KumarVijendra Pal Singh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anorexia Nervosa

Anorexia nervosa (AN) is a psychiatric condition characterized by severe weight loss and secondary problems associated with malnutrition. Here is the latest research on AN.