Experimental Infection of Foot and Mouth Disease in Indian Sheep and Goats

Frontiers in Veterinary Science
Madhanmohan MuthukrishnanSrinivasan Villuppanoor Alwar

Abstract

Foot-and-mouth disease (FMD) is an economically important contagious disease of livestock mainly cattle, buffalo, sheep, goats, and pig. There is limited data available on pathogenesis of foot and mouth disease in goats. In the study, the sheep and goats were infected experimentally with a serotype O foot-and-mouth disease virus by different challenge routes. The sheep and goats challenged by coronary band route and coronary band and intra-dermo-lingual route exhibited FMD clinical signs at 2-5 days post challenge. Whereas intra-dermo-lingual challenged sheep and goats did not exhibit FMD clinical signs. Live virus could be isolated from blood of infected sheep and goats at 2-5 days post challenge. Viral RNA could be detected from blood of infected sheep and goats at 1-10 days post challenge. The neutralizing antibody titre was detected at 10 days post challenge and maintained up to 35 days post challenge in all infected sheep and goats. Non structural protein (NSP) antibodies were detected as early as 5-10 days post challenge and remain positive up to 35 days post challenge in the infected sheep and goats. In conclusion, the pathogenesis of sheep and goats with serotype O foot and mouth disease virus by different challenge rou...Continue Reading

References

May 11, 2002·Epidemiology and Infection·S Alexandersen, A I Donaldson
Jun 26, 2002·The Veterinary Record·G J HughesA I Donaldson
Jan 14, 2003·Revue Scientifique Et Technique·R P Kitching, G J Hughes
Oct 30, 2004·Journal of Comparative Pathology·M QuanS Alexandersen
Apr 3, 2007·Journal of Virological Methods·Andrew E ShawDonald P King
Apr 27, 2007·Journal of Comparative Pathology·E RyanJ Brownlie
Nov 10, 2009·Comparative Immunology, Microbiology and Infectious Diseases·Muthukrishnan MadhanmohanVilluppanoor Alwar Srinivasan

❮ Previous
Next ❯

Citations

Feb 6, 2021·The Veterinary Clinics of North America. Food Animal Practice·Danelle A Bickett-WeddleCharles E McIntosh
Jun 18, 2021·EFSA Journal·UNKNOWN EFSA Panel on Animal Health and Welfare (AHAW)Helen Clare Roberts

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA
Assay
PCR

Software Mentioned

Rad iQ®5 optical system
Bio

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.