Experimental infection of horses with Bartonella henselae and Bartonella bovis

Journal of Veterinary Internal Medicine
J PalmeroB B Chomel

Abstract

Experimental infection of horses with Bartonella species is not documented. Determine clinical signs, hematologic changes, duration of bacteremia, and pattern of seroconversion in Bartonella henselae or Bartonella bovis-inoculated horses. Twelve (2 groups of 6) randomly selected healthy adult horses seronegative and culture negative for Bartonella spp. Experimental/observational study: Group I: B. henselae or saline control was inoculated intradermally into 4 naïve and 2 sentinel horses, respectively. Group II: same design was followed by means of B. bovis. Daily physical examinations, once weekly CBC, immunofluorescent antibody assay serology, real-time polymerase chain reaction (PCR), and twice weekly blood cultures were performed for 6 weeks and at postinoculation day 80 and 139. Bartonella alpha-Proteobacteria growth medium (BAPGM) enrichment blood culture was performed for horses that seroconverted to B. henselae antigens. Transient clinical signs consistent with bartonellosis occurred in some Bartonella-inoculated horses, but hematological alterations did not occur. Three B. henselae-inoculated horses seroconverted, whereas 1 B. bovis-inoculated horse was weakly seropositive. In Group I, B. henselae was amplified and sequ...Continue Reading

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Citations

Sep 25, 2012·Journal of Veterinary Internal Medicine·N A CherryE B Breitschwerdt
May 13, 2014·Journal of Veterinary Internal Medicine·E L SetlakweA L Johnson
Jun 16, 2010·PLoS Pathogens·Muriel Vayssier-TaussatChristoph Dehio
Jan 16, 2015·PLoS Neglected Tropical Diseases·Luiza Helena Urso PitassiPaulo Eduardo Neves Ferreira Velho
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Apr 24, 2019·Tropical Medicine and Infectious Disease·Mercedes A Cheslock, Monica E Embers

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